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- W2012382017 abstract "The current vaccine for tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is an attenuated strain of Mycobacterium bovis bacillus Calmette-Guerin (BCG). BCG has proven to be effective in children, however, efficacy wanes in adulthood. Lactoferrin, a natural protein with immunomodulatory properties, is a potential adjuvant candidate to enhance efficacy of BCG. These studies define bovine lactoferrin as an enhancer of the BCG vaccine, functioning in part by modulating macrophage ability to present antigen and stimulate T-cells. BCG-infected bone marrow derived macrophages (BMMs) cultured with bovine lactoferrin increased the number of MHC II+ expressing cells. Addition of IFN-γ and lactoferrin to BCG-infected BMMs enhanced MHC II expressiona dna increased the ratio of CD86/CD80. Lactoferrin treated BCG-infected BMMs were able to stimulate an increase in IFN-γ production from presensitized CD3+ splenocytes. Together, these results demonstrate that bovine lactoferrin is capable of modulating BCG-infected macrophages to enhance T-cell stimulation through increased surface expression of antigen presentation and co-stimulatory molecules, which potentially explains the observed in vivo bovine lactoferrin enhancement of BCG vaccine efficacy to protect against virulent MTB infection." @default.
- W2012382017 created "2016-06-24" @default.
- W2012382017 creator A5001969487 @default.
- W2012382017 creator A5058162161 @default.
- W2012382017 creator A5077775717 @default.
- W2012382017 date "2009-01-01" @default.
- W2012382017 modified "2023-10-09" @default.
- W2012382017 title "Influence of bovine lactoferrin on expression of presentation molecules on BCG-infected bone marrow derived macrophages" @default.
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- W2012382017 doi "https://doi.org/10.1016/j.biochi.2008.04.008" @default.
- W2012382017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2626195" @default.
- W2012382017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18486627" @default.
- W2012382017 hasPublicationYear "2009" @default.
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