FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012394202> ?p ?o ?g. }

• W2012394202 endingPage "568" @default.
• W2012394202 startingPage "559" @default.
• W2012394202 abstract "Acute pyelonephritis (APN) versus acute rejection (AR) is a frequently encountered diagnostic and therapeutic dilemma in kidney transplants. Variable culture results, overlapping histologic features, and persistent graft dysfunction despite antibiotics are frequently encountered. Therefore, we explored the utility of intragraft microRNA profiles to distinguish between allograft APN and AR.Between 2003 and 2011, we identified 49 patients with biopsy features of APN, within the first 2 years posttransplant. MicroRNA profiling was performed on 20 biopsies (normal kidney, n=4; unequivocal AR, n=5; features of APN, n=11).Only 32% (16/49) of the patients had concomitant positive urine cultures at biopsy, and in 8 of 16 patients, colony count was less than 10 CFU/mL. In 14 of 49 patients, positive urine culture did not coincide with the biopsy, and in 19 of 49 patients, urine cultures were negative. On microRNA profiling, good clustering was seen among the normal kidneys and among AR biopsies. Among the 11 biopsies with features of APN, 4 biopsies showed good clustering with a pattern distinct from AR; (these patients recovered graft function with antibiotics); 7 of 11 biopsies showed heterogeneity in microRNA profiles and variable outcomes with antibiotic treatment. We identified a panel of 25 microRNAs showing statistical difference in expression between AR and APN. MiR-99b, miR-23b let-7b-5p, miR-30a, and miR-145 were validated using qPCR.Allograft pyelonephritis can be a diagnostic and therapeutic challenge. A gestalt approach is required. In addition to histology and cultures, differential intragraft microRNA expression may prove helpful to distinguish APN from AR in renal allograft biopsies." @default.
• W2012394202 created "2016-06-24" @default.
• W2012394202 creator A5019293262 @default.
• W2012394202 creator A5027775199 @default.
• W2012394202 creator A5033500089 @default.
• W2012394202 creator A5043954064 @default.
• W2012394202 creator A5044705669 @default.
• W2012394202 creator A5046236534 @default.
• W2012394202 creator A5068800992 @default.
• W2012394202 creator A5070749654 @default.
• W2012394202 creator A5073214741 @default.
• W2012394202 creator A5077634371 @default.
• W2012394202 creator A5085204314 @default.
• W2012394202 date "2014-03-15" @default.
• W2012394202 modified "2023-10-06" @default.
• W2012394202 title "Acute Pyelonephritis in Renal Allografts–A New Role for MicroRNAs?" @default.
• W2012394202 cites W1567903773 @default.
• W2012394202 cites W1605178647 @default.
• W2012394202 cites W1669106649 @default.
• W2012394202 cites W1963483967 @default.
• W2012394202 cites W1966288009 @default.
• W2012394202 cites W1974820619 @default.
• W2012394202 cites W1977215885 @default.
• W2012394202 cites W1978889837 @default.
• W2012394202 cites W1982083339 @default.
• W2012394202 cites W2013443950 @default.
• W2012394202 cites W2021790643 @default.
• W2012394202 cites W2029339985 @default.
• W2012394202 cites W2037487823 @default.
• W2012394202 cites W2057588450 @default.
• W2012394202 cites W2063229108 @default.
• W2012394202 cites W2066228337 @default.
• W2012394202 cites W2069691262 @default.
• W2012394202 cites W2069954171 @default.
• W2012394202 cites W2073297261 @default.
• W2012394202 cites W2080924394 @default.
• W2012394202 cites W2086661384 @default.
• W2012394202 cites W2095315056 @default.
• W2012394202 cites W2135061646 @default.
• W2012394202 cites W2135858383 @default.
• W2012394202 cites W2141530853 @default.
• W2012394202 cites W2142288396 @default.
• W2012394202 cites W2145646761 @default.
• W2012394202 cites W2154028793 @default.
• W2012394202 cites W2170688212 @default.
• W2012394202 cites W2170854705 @default.
• W2012394202 cites W2171549183 @default.
• W2012394202 cites W2337008570 @default.
• W2012394202 doi "https://doi.org/10.1097/01.tp.0000441322.95539.b3" @default.
• W2012394202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090250" @default.
• W2012394202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521778" @default.
• W2012394202 hasPublicationYear "2014" @default.
• W2012394202 type Work @default.
• W2012394202 sameAs 2012394202 @default.
• W2012394202 citedByCount "34" @default.
• W2012394202 countsByYear W20123942022014 @default.
• W2012394202 countsByYear W20123942022015 @default.
• W2012394202 countsByYear W20123942022016 @default.
• W2012394202 countsByYear W20123942022017 @default.
• W2012394202 countsByYear W20123942022018 @default.
• W2012394202 countsByYear W20123942022019 @default.
• W2012394202 countsByYear W20123942022020 @default.
• W2012394202 countsByYear W20123942022021 @default.
• W2012394202 countsByYear W20123942022022 @default.
• W2012394202 countsByYear W20123942022023 @default.
• W2012394202 crossrefType "journal-article" @default.
• W2012394202 hasAuthorship W2012394202A5019293262 @default.
• W2012394202 hasAuthorship W2012394202A5027775199 @default.
• W2012394202 hasAuthorship W2012394202A5033500089 @default.
• W2012394202 hasAuthorship W2012394202A5043954064 @default.
• W2012394202 hasAuthorship W2012394202A5044705669 @default.
• W2012394202 hasAuthorship W2012394202A5046236534 @default.
• W2012394202 hasAuthorship W2012394202A5068800992 @default.
• W2012394202 hasAuthorship W2012394202A5070749654 @default.
• W2012394202 hasAuthorship W2012394202A5073214741 @default.
• W2012394202 hasAuthorship W2012394202A5077634371 @default.
• W2012394202 hasAuthorship W2012394202A5085204314 @default.
• W2012394202 hasBestOaLocation W20123942022 @default.
• W2012394202 hasConcept C104317684 @default.
• W2012394202 hasConcept C126322002 @default.
• W2012394202 hasConcept C142724271 @default.
• W2012394202 hasConcept C145059251 @default.
• W2012394202 hasConcept C2775934546 @default.
• W2012394202 hasConcept C2779384505 @default.
• W2012394202 hasConcept C2780026642 @default.
• W2012394202 hasConcept C2780091579 @default.
• W2012394202 hasConcept C2780801072 @default.
• W2012394202 hasConcept C55493867 @default.
• W2012394202 hasConcept C71924100 @default.
• W2012394202 hasConcept C86803240 @default.
• W2012394202 hasConceptScore W2012394202C104317684 @default.
• W2012394202 hasConceptScore W2012394202C126322002 @default.
• W2012394202 hasConceptScore W2012394202C142724271 @default.
• W2012394202 hasConceptScore W2012394202C145059251 @default.
• W2012394202 hasConceptScore W2012394202C2775934546 @default.
• W2012394202 hasConceptScore W2012394202C2779384505 @default.
• W2012394202 hasConceptScore W2012394202C2780026642 @default.
• W2012394202 hasConceptScore W2012394202C2780091579 @default.

• next