FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012399033> ?p ?o ?g. }

• W2012399033 endingPage "443" @default.
• W2012399033 startingPage "435" @default.
• W2012399033 abstract "We showed previously that treatment of cultured rabbit lens epithelial cells (LECs) with hyperbaric oxygen (HBO) produced DNA strand-breaks, caused reversible inhibition of protein synthesis and induced the synthesis of a 32 kD protein. In the present work, we employed immunostaining procedures to identify the 32 kD protein as heme oxygenase-1 (HO-1). Increased synthesis of the enzyme was observed as early as 12 hr after HBO-treatment, reached a maximum at 18 hr and was not detectable at 36 hr. Exposure of the cells to hemin also increased the synthesis of HO-1. An HBO-induced inhibition of protein synthesis and the subsequent induction of HO-1 was also observed in the capsule-epithelium of cultured rabbit lenses. For both LECs and the cultured lens, only HO-1 and not heme oxygenase-2 was HBO-inducible. Use of the antioxidant dimethylthiourea with HBO-treated lenses or LECs did not alter the observed effects on protein synthesis or the induction of HO-1. In contrast to results obtained with 50 atm O2, a pressure of 25 atm O2inhibited protein synthesis only slightly and failed to induce synthesis of the 32 kD protein (although, as shown previously, identical exposure of LECs to 25 atm O2significantly damaged DNA). Inhibition of protein synthesis in LECs and cultured lenses with the use of puromycin also induced synthesis of HO-1. Both hemin (10 μm), a source of iron, and 50 atm O2produced a three-fold increase in the concentration of ferritin, a natural iron chelator, in LECs two days after exposure; no effects on ferritin levels were observed after 1 or 3 days. The finding that the increase in ferritin concentration occurred in the cells significantly after hemin- or HBO-induced synthesis of heme oxygenase indicates that chelatable iron rather than the heme molecule itself may have been the primary agent responsible for inducing ferritin synthesis. The data suggest that HBO-induced synthesis of HO-1 in the lens epithelium may be the result of an inhibition of protein synthesis, possibly leading to an accumulation of heme, rather than a direct protective response against oxidative stress." @default.
• W2012399033 created "2016-06-24" @default.
• W2012399033 creator A5002809927 @default.
• W2012399033 creator A5028137347 @default.
• W2012399033 creator A5028719097 @default.
• W2012399033 creator A5030539424 @default.
• W2012399033 creator A5047651166 @default.
• W2012399033 creator A5069767010 @default.
• W2012399033 date "1997-09-01" @default.
• W2012399033 modified "2023-10-15" @default.
• W2012399033 title "Heme Oxygenase Synthesis is Induced in Cultured Lens Epithelium by Hyperbaric Oxygen or Puromycin" @default.
• W2012399033 cites W1501532586 @default.
• W2012399033 cites W1521258655 @default.
• W2012399033 cites W1531497588 @default.
• W2012399033 cites W1559821198 @default.
• W2012399033 cites W1621595817 @default.
• W2012399033 cites W1936380547 @default.
• W2012399033 cites W1950817823 @default.
• W2012399033 cites W1966582616 @default.
• W2012399033 cites W1969048943 @default.
• W2012399033 cites W1974371318 @default.
• W2012399033 cites W1974662673 @default.
• W2012399033 cites W1993596487 @default.
• W2012399033 cites W1993780014 @default.
• W2012399033 cites W2001201638 @default.
• W2012399033 cites W2004302011 @default.
• W2012399033 cites W2009512469 @default.
• W2012399033 cites W2017897544 @default.
• W2012399033 cites W2022437540 @default.
• W2012399033 cites W2024087110 @default.
• W2012399033 cites W2028778467 @default.
• W2012399033 cites W2031044837 @default.
• W2012399033 cites W2041553103 @default.
• W2012399033 cites W2047908300 @default.
• W2012399033 cites W2050107143 @default.
• W2012399033 cites W2058481249 @default.
• W2012399033 cites W2066033513 @default.
• W2012399033 cites W2067345422 @default.
• W2012399033 cites W2074235384 @default.
• W2012399033 cites W2074535080 @default.
• W2012399033 cites W2076014304 @default.
• W2012399033 cites W2092983592 @default.
• W2012399033 cites W2095220059 @default.
• W2012399033 cites W2100837269 @default.
• W2012399033 cites W2115485369 @default.
• W2012399033 cites W2124433916 @default.
• W2012399033 cites W2127223050 @default.
• W2012399033 cites W2169946155 @default.
• W2012399033 cites W2204618410 @default.
• W2012399033 cites W2894646342 @default.
• W2012399033 doi "https://doi.org/10.1006/exer.1997.0356" @default.
• W2012399033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9299180" @default.
• W2012399033 hasPublicationYear "1997" @default.
• W2012399033 type Work @default.
• W2012399033 sameAs 2012399033 @default.
• W2012399033 citedByCount "30" @default.
• W2012399033 countsByYear W20123990332012 @default.
• W2012399033 countsByYear W20123990332014 @default.
• W2012399033 countsByYear W20123990332015 @default.
• W2012399033 countsByYear W20123990332017 @default.
• W2012399033 countsByYear W20123990332022 @default.
• W2012399033 crossrefType "journal-article" @default.
• W2012399033 hasAuthorship W2012399033A5002809927 @default.
• W2012399033 hasAuthorship W2012399033A5028137347 @default.
• W2012399033 hasAuthorship W2012399033A5028719097 @default.
• W2012399033 hasAuthorship W2012399033A5030539424 @default.
• W2012399033 hasAuthorship W2012399033A5047651166 @default.
• W2012399033 hasAuthorship W2012399033A5069767010 @default.
• W2012399033 hasConcept C153911025 @default.
• W2012399033 hasConcept C181199279 @default.
• W2012399033 hasConcept C185592680 @default.
• W2012399033 hasConcept C2776217839 @default.
• W2012399033 hasConcept C2777723881 @default.
• W2012399033 hasConcept C2779200571 @default.
• W2012399033 hasConcept C2779219270 @default.
• W2012399033 hasConcept C3675279 @default.
• W2012399033 hasConcept C552990157 @default.
• W2012399033 hasConcept C55493867 @default.
• W2012399033 hasConcept C64241487 @default.
• W2012399033 hasConcept C86803240 @default.
• W2012399033 hasConceptScore W2012399033C153911025 @default.
• W2012399033 hasConceptScore W2012399033C181199279 @default.
• W2012399033 hasConceptScore W2012399033C185592680 @default.
• W2012399033 hasConceptScore W2012399033C2776217839 @default.
• W2012399033 hasConceptScore W2012399033C2777723881 @default.
• W2012399033 hasConceptScore W2012399033C2779200571 @default.
• W2012399033 hasConceptScore W2012399033C2779219270 @default.
• W2012399033 hasConceptScore W2012399033C3675279 @default.
• W2012399033 hasConceptScore W2012399033C552990157 @default.
• W2012399033 hasConceptScore W2012399033C55493867 @default.
• W2012399033 hasConceptScore W2012399033C64241487 @default.
• W2012399033 hasConceptScore W2012399033C86803240 @default.
• W2012399033 hasIssue "3" @default.
• W2012399033 hasLocation W20123990331 @default.
• W2012399033 hasLocation W20123990332 @default.
• W2012399033 hasOpenAccess W2012399033 @default.
• W2012399033 hasPrimaryLocation W20123990331 @default.
• W2012399033 hasRelatedWork W1832224497 @default.

• next