Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012399470> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2012399470 endingPage "492" @default.
- W2012399470 startingPage "488" @default.
- W2012399470 abstract "To map the proliferative activity of corneal cells during wound healing following photorefractive keratectomy (PRK) and to compare two markers for proliferation.PRK, 5- mm in diameter with a -6 D setting, was performed in one eye of 28 New Zealand White Rabbits. The rabbits were sacrificed at time points between 12 hours and three months after surgery. The treated and fellow corneas were fixed in 10% formaldehyde, paraffin embedded, and immunohistochemically stained for proliferate cell nuclear antigen (PCNA) and at one time point, 1 week, also for Ki-67.Following initial sliding of the epithelial cells, the proliferative activity in the wound area starts in the leading edge (24 hours) and is spread towards the periphery. The proliferative activity peaks after one week and subsides during the following two weeks. Early (24 hours) proliferative activity is also seen in the limbal epithelium which peaks after three days. The keratocytes express PCNA in the peripheral stroma 48 hours after injury. They then also migrate to repopulate the stroma under the wound area. The expression period lasts 1 week and subsides the following week. Leukocytes are found in the wound as early as 12 hours after injury. The cells disappear around the time of epithelial wound closure, i.e. after 3 days. The two proliferative markers PCNA and KI 67 show a similar distribution after surgery.Epithelial proliferative activity starts earlier after injury, and is preceded by leukocyte presence in the wound. The PCNA expression starts later in the keratocytes but lasts somewhat longer (3 weeks). PCNA expression appears more efficient than Ki-67 to show proliferative activity of slow cycling cells in the cornea" @default.
- W2012399470 created "2016-06-24" @default.
- W2012399470 creator A5042455111 @default.
- W2012399470 creator A5051689665 @default.
- W2012399470 creator A5055281830 @default.
- W2012399470 creator A5061644055 @default.
- W2012399470 date "2001-10-01" @default.
- W2012399470 modified "2023-10-17" @default.
- W2012399470 title "Cellular proliferation and leukocyte infiltration in the rabbit cornea after photorefractive keratectomy" @default.
- W2012399470 cites W1875174047 @default.
- W2012399470 cites W2006106964 @default.
- W2012399470 cites W2015999608 @default.
- W2012399470 cites W2018717230 @default.
- W2012399470 cites W2023444709 @default.
- W2012399470 cites W2030424037 @default.
- W2012399470 cites W2040016239 @default.
- W2012399470 cites W2091986844 @default.
- W2012399470 cites W2094008821 @default.
- W2012399470 cites W2154536753 @default.
- W2012399470 cites W2180918597 @default.
- W2012399470 cites W2328081002 @default.
- W2012399470 doi "https://doi.org/10.1034/j.1600-0420.2001.790512.x" @default.
- W2012399470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11594985" @default.
- W2012399470 hasPublicationYear "2001" @default.
- W2012399470 type Work @default.
- W2012399470 sameAs 2012399470 @default.
- W2012399470 citedByCount "30" @default.
- W2012399470 countsByYear W20123994702012 @default.
- W2012399470 countsByYear W20123994702013 @default.
- W2012399470 countsByYear W20123994702014 @default.
- W2012399470 countsByYear W20123994702015 @default.
- W2012399470 countsByYear W20123994702016 @default.
- W2012399470 countsByYear W20123994702019 @default.
- W2012399470 countsByYear W20123994702020 @default.
- W2012399470 countsByYear W20123994702021 @default.
- W2012399470 countsByYear W20123994702022 @default.
- W2012399470 crossrefType "journal-article" @default.
- W2012399470 hasAuthorship W2012399470A5042455111 @default.
- W2012399470 hasAuthorship W2012399470A5051689665 @default.
- W2012399470 hasAuthorship W2012399470A5055281830 @default.
- W2012399470 hasAuthorship W2012399470A5061644055 @default.
- W2012399470 hasBestOaLocation W20123994701 @default.
- W2012399470 hasConcept C118487528 @default.
- W2012399470 hasConcept C121332964 @default.
- W2012399470 hasConcept C141071460 @default.
- W2012399470 hasConcept C142724271 @default.
- W2012399470 hasConcept C153400128 @default.
- W2012399470 hasConcept C204232928 @default.
- W2012399470 hasConcept C2776882836 @default.
- W2012399470 hasConcept C2779257441 @default.
- W2012399470 hasConcept C2780269544 @default.
- W2012399470 hasConcept C2780603455 @default.
- W2012399470 hasConcept C34688535 @default.
- W2012399470 hasConcept C52124034 @default.
- W2012399470 hasConcept C529295009 @default.
- W2012399470 hasConcept C54355233 @default.
- W2012399470 hasConcept C62112901 @default.
- W2012399470 hasConcept C71924100 @default.
- W2012399470 hasConcept C86803240 @default.
- W2012399470 hasConcept C97355855 @default.
- W2012399470 hasConceptScore W2012399470C118487528 @default.
- W2012399470 hasConceptScore W2012399470C121332964 @default.
- W2012399470 hasConceptScore W2012399470C141071460 @default.
- W2012399470 hasConceptScore W2012399470C142724271 @default.
- W2012399470 hasConceptScore W2012399470C153400128 @default.
- W2012399470 hasConceptScore W2012399470C204232928 @default.
- W2012399470 hasConceptScore W2012399470C2776882836 @default.
- W2012399470 hasConceptScore W2012399470C2779257441 @default.
- W2012399470 hasConceptScore W2012399470C2780269544 @default.
- W2012399470 hasConceptScore W2012399470C2780603455 @default.
- W2012399470 hasConceptScore W2012399470C34688535 @default.
- W2012399470 hasConceptScore W2012399470C52124034 @default.
- W2012399470 hasConceptScore W2012399470C529295009 @default.
- W2012399470 hasConceptScore W2012399470C54355233 @default.
- W2012399470 hasConceptScore W2012399470C62112901 @default.
- W2012399470 hasConceptScore W2012399470C71924100 @default.
- W2012399470 hasConceptScore W2012399470C86803240 @default.
- W2012399470 hasConceptScore W2012399470C97355855 @default.
- W2012399470 hasIssue "5" @default.
- W2012399470 hasLocation W20123994701 @default.
- W2012399470 hasLocation W20123994702 @default.
- W2012399470 hasOpenAccess W2012399470 @default.
- W2012399470 hasPrimaryLocation W20123994701 @default.
- W2012399470 hasRelatedWork W1965374968 @default.
- W2012399470 hasRelatedWork W1978512392 @default.
- W2012399470 hasRelatedWork W2008262225 @default.
- W2012399470 hasRelatedWork W2017108020 @default.
- W2012399470 hasRelatedWork W2049086211 @default.
- W2012399470 hasRelatedWork W2090997908 @default.
- W2012399470 hasRelatedWork W2287125600 @default.
- W2012399470 hasRelatedWork W2372383041 @default.
- W2012399470 hasRelatedWork W2385533975 @default.
- W2012399470 hasRelatedWork W4234678434 @default.
- W2012399470 hasVolume "79" @default.
- W2012399470 isParatext "false" @default.
- W2012399470 isRetracted "false" @default.
- W2012399470 magId "2012399470" @default.
- W2012399470 workType "article" @default.