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• W2012399854 abstract "Successful cytokinesis is critical for maintaining genome stability [1Eggert U.S. Mitchison T.J. Field C.M. Animal cytokinesis: From parts list to mechanisms.Annu. Rev. Biochem. 2006; 75: 543-566Crossref PubMed Scopus (331) Google Scholar, 2Glotzer M. The 3Ms of central spindle assembly: Microtubules, motors and MAPs.Nat. Rev. Mol. Cell Biol. 2009; 10: 9-20Crossref PubMed Scopus (256) Google Scholar] and requires the assembly of a robust central spindle to specify the cleavage furrow position [3Inoue Y.H. Savoian M.S. Suzuki T. Máthé E. Yamamoto M.T. Glover D.M. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.J. Cell Biol. 2004; 166: 49-60Crossref PubMed Scopus (116) Google Scholar], to prevent separated chromosomes from coming back together [4Straight A.F. Cheung A. Limouze J. Chen I. Westwood N.J. Sellers J.R. Mitchison T.J. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.Science. 2003; 299: 1743-1747Crossref PubMed Scopus (1058) Google Scholar], and to contribute to midbody abscission [5Jiang W. Jimenez G. Wells N.J. Hope T.J. Wahl G.M. Hunter T. Fukunaga R. PRC1: A human mitotic spindle-associated CDK substrate protein required for cytokinesis.Mol. Cell. 1998; 2: 877-885Abstract Full Text Full Text PDF PubMed Google Scholar, 6Mollinari C. Kleman J.P. Saoudi Y. Jablonski S.A. Perard J. Yen T.J. Margolis R.L. Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not.Mol. Biol. Cell. 2005; 16: 1043-1055Crossref PubMed Scopus (81) Google Scholar]. A proper central spindle is assembled and maintained by a number of microtubule-associated and molecular motor proteins that sort microtubules into bundles with their plus ends overlapping at the center [1Eggert U.S. Mitchison T.J. Field C.M. Animal cytokinesis: From parts list to mechanisms.Annu. Rev. Biochem. 2006; 75: 543-566Crossref PubMed Scopus (331) Google Scholar, 2Glotzer M. The 3Ms of central spindle assembly: Microtubules, motors and MAPs.Nat. Rev. Mol. Cell Biol. 2009; 10: 9-20Crossref PubMed Scopus (256) Google Scholar]. The mechanisms by which different factors organize the central spindle microtubules remain unclear. We found that perturbation of the minus-end-directed Kinesin-14 HSET increased the frequency of polyploid cells, which resulted from a failure in cytokinesis. In addition, HSET knockdown resulted in severe midzone microtubule organization, most notably at microtubule minus ends, as well as mislocalization of several midbody-associated proteins. Biochemical analysis showed that both human HSET and Xenopus XCTK2 cofractionated with the γ-tubulin ring complexes on sucrose gradients and that XCTK2 associated with γ-tubulin and Xgrip109 by immunoprecipitation. Our data reveal the novel finding that a minus-end-directed motor contributes to the organization and stability of the central spindle, which is needed for proper cytokinesis." @default.
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• W2012399854 date "2010-05-01" @default.
• W2012399854 modified "2023-10-15" @default.
• W2012399854 title "Proper Organization of Microtubule Minus Ends Is Needed for Midzone Stability and Cytokinesis" @default.
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• W2012399854 doi "https://doi.org/10.1016/j.cub.2010.03.067" @default.
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