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• W2012405907 abstract "The activation of the calcineurin–nuclear factor of activated T cells cascade during the development of pressure‐overload cardiac hypertrophy has been previously reported in a number of studies. In addition, numerous pharmacological studies involving calcineurin inhibitors such as FK506 and cyclosporine A have now demonstrated that these agents can prevent such hypertrophic responses in the heart. However, little is known regarding the roles of the calcineurin downstream effecter – nuclear factor of activated T cells. Our present study has further examined the roles of nuclear factor of activated T cells in pressure‐overload cardiac hypertrophy by employing a recently developed cell‐permeable nuclear factor of activated T cells inhibitor peptide. Rat hearts were subjected to pressure overload attributable by 4 weeks of aortic banding, and then treated with this cell‐permeable nuclear factor of activated T cells inhibitor peptide and a control peptide. Treatment with the inhibitor was found to significantly decrease the heart weight/body weight ratio, the size of cardiac myocytes, and the serum brain natriuretic peptide and atrial natriuretic peptide levels. These results suggest that nuclear factor of activated T cells functions in a key role in the development of cardiac hypertrophy during pressure overload. Inhibition of nuclear factor of activated T cells by a specific inhibitor peptide is a suitable method for characterization of the molecular mechanisms underlying cardiac hypertrophy as well as in the search for new promising therapies for disease." @default.
• W2012405907 created "2016-06-24" @default.
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• W2012405907 date "2006-03-01" @default.
• W2012405907 modified "2023-10-16" @default.
• W2012405907 title "A Cell-permeable NFAT Inhibitor Peptide Prevents Pressure-Overload Cardiac Hypertrophy" @default.
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• W2012405907 doi "https://doi.org/10.1111/j.1747-0285.2006.00360.x" @default.
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