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- W2012406493 abstract "Induction of the drug-metabolising enzyme systems is a major cause of clinically relevant drug interactions. The potential of a drug to engage in such interactions may be assessed in in vitro systems such as precision-cut tissue slices.Precision-cut tissue slices have a number of important advantages compared with the use of cells in culture, especially when tissues with a heterogeneous cellular population are concerned.Extensive studies concerned with the induction of cytochrome P450 and Phase II enzymes in precision-cut tissue slices from various animal and human tissues, such as liver, lung and intestine, using established inducing agents have revealed that slices mimic the in vivo situation.Precision-cut tissue slices is a reliable, informative and cost-effective technique for assessing the potential of chemicals to up-regulate drug-metabolising enzyme systems." @default.
- W2012406493 created "2016-06-24" @default.
- W2012406493 creator A5087281525 @default.
- W2012406493 date "2012-06-28" @default.
- W2012406493 modified "2023-09-28" @default.
- W2012406493 title "Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices" @default.
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- W2012406493 doi "https://doi.org/10.3109/00498254.2012.698766" @default.
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