FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012413811> ?p ?o ?g. }

• W2012413811 endingPage "1262" @default.
• W2012413811 startingPage "1255" @default.
• W2012413811 abstract "The matricellular angiogenesis inhibitor, thrombospondin (TSP) 2, has been shown to be an important modulator of wound healing and the foreign body response. Specifically, TSP2-null mice display improved healing with minimal scarring and form well-vascularized foreign body capsules. In this study we performed subcutaneous implantation of sponges and investigated the resulting angiogenic and fibrogenic responses. Histological and immunohistochemical analysis of sponges, excised at 7, 14, and 21 days after implantation, revealed significant differences between TSP2-null and wild-type mice. Most notably, TSP2-null mice exhibited increased angiogenesis and fibrotic encapsulation of the sponge. However, invasion of dense tissue was compromised, even though its overall density was increased. Furthermore, histomorphometry and biochemical assays demonstrated a significant increase in the extracellular distribution of matrix metalloproteinase (MMP) 2, but no change in the levels of active transforming growth factor-beta(1). The alterations in neovascularization, dense tissue invasion, and MMP2 in TSP2-null mice coincided with the deposition of TSP2 in the extracellular matrix of wild-type animals. These observations support the proposed role of TSP2 as a modulator of angiogenesis and matrix remodeling during tissue repair. In addition, they provide in vivo evidence for a newly proposed function of TSP2 as a modulator of extracellular MMP2 levels." @default.
• W2012413811 created "2016-06-24" @default.
• W2012413811 creator A5019694310 @default.
• W2012413811 creator A5043009176 @default.
• W2012413811 creator A5063109099 @default.
• W2012413811 creator A5066869880 @default.
• W2012413811 creator A5074350514 @default.
• W2012413811 date "2001-10-01" @default.
• W2012413811 modified "2023-10-17" @default.
• W2012413811 title "Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null Mice" @default.
• W2012413811 cites W1549631663 @default.
• W2012413811 cites W1946162597 @default.
• W2012413811 cites W1964632069 @default.
• W2012413811 cites W1993360635 @default.
• W2012413811 cites W1995185323 @default.
• W2012413811 cites W1997693327 @default.
• W2012413811 cites W2022665089 @default.
• W2012413811 cites W2024808467 @default.
• W2012413811 cites W2028147193 @default.
• W2012413811 cites W2032002052 @default.
• W2012413811 cites W2033260397 @default.
• W2012413811 cites W2039898357 @default.
• W2012413811 cites W2044927029 @default.
• W2012413811 cites W2045447884 @default.
• W2012413811 cites W2050577046 @default.
• W2012413811 cites W2058581224 @default.
• W2012413811 cites W2060074114 @default.
• W2012413811 cites W2062023732 @default.
• W2012413811 cites W2063349940 @default.
• W2012413811 cites W2069457579 @default.
• W2012413811 cites W2070742907 @default.
• W2012413811 cites W2085939705 @default.
• W2012413811 cites W2087749727 @default.
• W2012413811 cites W2090346571 @default.
• W2012413811 cites W2110310870 @default.
• W2012413811 cites W2138423846 @default.
• W2012413811 cites W2148923267 @default.
• W2012413811 cites W2162838387 @default.
• W2012413811 cites W2163862629 @default.
• W2012413811 cites W2288757746 @default.
• W2012413811 cites W2414987611 @default.
• W2012413811 cites W2430493561 @default.
• W2012413811 cites W283047911 @default.
• W2012413811 cites W71200683 @default.
• W2012413811 doi "https://doi.org/10.1016/s0002-9440(10)62512-6" @default.
• W2012413811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850515" @default.
• W2012413811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11583953" @default.
• W2012413811 hasPublicationYear "2001" @default.
• W2012413811 type Work @default.
• W2012413811 sameAs 2012413811 @default.
• W2012413811 citedByCount "105" @default.
• W2012413811 countsByYear W20124138112012 @default.
• W2012413811 countsByYear W20124138112013 @default.
• W2012413811 countsByYear W20124138112014 @default.
• W2012413811 countsByYear W20124138112015 @default.
• W2012413811 countsByYear W20124138112016 @default.
• W2012413811 countsByYear W20124138112018 @default.
• W2012413811 countsByYear W20124138112019 @default.
• W2012413811 countsByYear W20124138112020 @default.
• W2012413811 countsByYear W20124138112022 @default.
• W2012413811 crossrefType "journal-article" @default.
• W2012413811 hasAuthorship W2012413811A5019694310 @default.
• W2012413811 hasAuthorship W2012413811A5043009176 @default.
• W2012413811 hasAuthorship W2012413811A5063109099 @default.
• W2012413811 hasAuthorship W2012413811A5066869880 @default.
• W2012413811 hasAuthorship W2012413811A5074350514 @default.
• W2012413811 hasBestOaLocation W20124138112 @default.
• W2012413811 hasConcept C109523444 @default.
• W2012413811 hasConcept C142724271 @default.
• W2012413811 hasConcept C167814343 @default.
• W2012413811 hasConcept C189165786 @default.
• W2012413811 hasConcept C203014093 @default.
• W2012413811 hasConcept C2775893135 @default.
• W2012413811 hasConcept C2776056115 @default.
• W2012413811 hasConcept C2778271429 @default.
• W2012413811 hasConcept C2780269544 @default.
• W2012413811 hasConcept C2780394083 @default.
• W2012413811 hasConcept C2910422434 @default.
• W2012413811 hasConcept C502942594 @default.
• W2012413811 hasConcept C55493867 @default.
• W2012413811 hasConcept C55728118 @default.
• W2012413811 hasConcept C71924100 @default.
• W2012413811 hasConcept C86803240 @default.
• W2012413811 hasConcept C95444343 @default.
• W2012413811 hasConceptScore W2012413811C109523444 @default.
• W2012413811 hasConceptScore W2012413811C142724271 @default.
• W2012413811 hasConceptScore W2012413811C167814343 @default.
• W2012413811 hasConceptScore W2012413811C189165786 @default.
• W2012413811 hasConceptScore W2012413811C203014093 @default.
• W2012413811 hasConceptScore W2012413811C2775893135 @default.
• W2012413811 hasConceptScore W2012413811C2776056115 @default.
• W2012413811 hasConceptScore W2012413811C2778271429 @default.
• W2012413811 hasConceptScore W2012413811C2780269544 @default.
• W2012413811 hasConceptScore W2012413811C2780394083 @default.
• W2012413811 hasConceptScore W2012413811C2910422434 @default.
• W2012413811 hasConceptScore W2012413811C502942594 @default.
• W2012413811 hasConceptScore W2012413811C55493867 @default.
• W2012413811 hasConceptScore W2012413811C55728118 @default.

• next