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- W2012424390 abstract "There has been a recent growth in empirical research on assent with pediatric populations, due in part, to the demand for increased participation of this population in biomedical research. Despite methodological limitations, studies of adolescent capacities to assent have advanced and identified a number of salient psychological and social variables that are key to understanding assent.The authors review a subsection of the empirical literature on adolescent assent focusing primarily on asthma and cancer therapeutic research; adolescent competencies to assent to these studies; perceptions of protocol risk and benefit; the affects of various social context variables on adolescent research participation decision making; and the inter-relatedness of these psychological and social factors.Contemporary studies of assent, using multivariate methods and updated approaches to statistical modeling, have revealed the importance of studying the intercorrelation between adolescents' psychological capacities and their ability to employ these capacities in family and medical decision-making contexts. Understanding these dynamic relationships will enable researchers and ethicists to develop assent procedures that respect the authority of parents, while at the same time accord adolescents appropriate decision-making autonomy.Reviews of empirical literature on the assent process reveal that adolescents possess varying capacities for biomedical research participation decision making depending on their maturity and the social context in which the decision is made. The relationship between adolescents and physician-investigators can be used to attenuate concerns about research protocols and clarify risk and benefit information so adolescents, in concert with their families, can make the most informed and ethical decisions. Future assent researchers will be better able to navigate the complicated interplay of contextual and developmental factors and develop the empirical bases for research enrollment protocols that will support increased involvement of adolescents in biomedical research." @default.
- W2012424390 created "2016-06-24" @default.
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- W2012424390 date "2013-07-01" @default.
- W2012424390 modified "2023-10-03" @default.
- W2012424390 title "Empirically Derived Knowledge on Adolescent Assent to Pediatric Biomedical Research" @default.
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- W2012424390 doi "https://doi.org/10.1080/21507716.2013.806967" @default.
- W2012424390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3728675" @default.
- W2012424390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23914304" @default.
- W2012424390 hasPublicationYear "2013" @default.
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