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- W2012425496 abstract "The production of cytokines involved in platelet generation, including inter-leukin (IL)-3, IL-6 and IL-11, is stimulated by IL-2. However, the platelet number has been shown to decrease on IL-2 cancer therapy, and this side effect depends on the enhanced peripheral platelet destruction following the activation of the macrophage system by IL-2 itself. Our previous studies showed that IL-2-induced macrophage activation may be counteracted by the pineal hormone melatonin (MLT). On this basis, a pilot study with IL-2 plus MLT was performed to evaluate its influence on the platelet number in cancer patients with persistent thrombocytopenia. The study included 20 advanced solid tumor patients, who received IL-2 at 3 million IU/day s.c. for 6 days/ week for 4 weeks in association with MLT (40 mg/day orally). A normalization of the platelet number was achieved in 14/20 (70%) patients. This pilot study shows that the therapy with low-dose IL-2 plus MLT, in addition to its previously described antitumor activity, may also be effective in the treatment of cancer-related thrombocytopenia." @default.
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- W2012425496 date "1995-01-01" @default.
- W2012425496 modified "2023-09-27" @default.
- W2012425496 title "A Biological Study on the Efficacy of Low–Dose Subcutaneous lnterleukin–2 plus Melatonin in the Treatment of Cancer–Related Thrombocytopenia" @default.
- W2012425496 doi "https://doi.org/10.1159/000227489" @default.
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