FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012441202> ?p ?o ?g. }

• W2012441202 endingPage "H68" @default.
• W2012441202 startingPage "H62" @default.
• W2012441202 abstract "Hypoxia from birth increases resistance to myocardial ischemia in infant rabbits. We hypothesized that increased cardioprotection in hearts chronically hypoxic from birth persists following development in a normoxic environment and involves increased activation of nitric oxide synthase (NOS) and ATP-dependent K (K ATP ) channels. Resistance to myocardial ischemia was determined in rabbits raised from birth to 10 days of age in a normoxic (Fi O 2 = 0.21) or hypoxic (Fi O 2 = 0.12) environment and subsequently exposed to normoxia for up to 60 days of age. Isolated hearts ( n = 8/group) were subjected to 30 min of global ischemia followed by 35 min of reperfusion. At 10 days of age, resistance to myocardial ischemia (percent recovery postischemic recovery left ventricular developed pressure) was higher in chronically hypoxic hearts (68 ± 4%) than normoxic controls (43 ± 4%). At 10 days of age, N G -nitro-l-arginine methyl ester (200 μM) and glibenclamide (3 μM) abolished the cardioprotective effects of chronic hypoxia (45 ± 4% and 46 ± 5%, respectively) but had no effect on normoxic hearts. At 30 days of age resistance to ischemia in normoxic hearts declined (36 ± 5%). However, in hearts subjected to chronic hypoxia from birth to 10 days and then exposed to normoxia until 30 days of age, resistance to ischemia persisted (63 ± 4%). l-NAME or glibenclamide abolished cardioprotection in previously hypoxic hearts (37 ± 4% and 39 ± 5%, respectively) but had no effect on normoxic hearts. Increased cardioprotection was lost by 60 days. We conclude that cardioprotection conferred by adaptation to hypoxia from birth persists on subsequent exposure to normoxia and is associated with enhanced NOS activity and activation of K ATP channels." @default.
• W2012441202 created "2016-06-24" @default.
• W2012441202 creator A5011693177 @default.
• W2012441202 creator A5011755778 @default.
• W2012441202 creator A5020263309 @default.
• W2012441202 creator A5030692703 @default.
• W2012441202 creator A5032980898 @default.
• W2012441202 creator A5059297531 @default.
• W2012441202 creator A5067265472 @default.
• W2012441202 creator A5081559897 @default.
• W2012441202 date "2005-01-01" @default.
• W2012441202 modified "2023-10-16" @default.
• W2012441202 title "Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and K_ATP channels" @default.
• W2012441202 cites W1940623 @default.
• W2012441202 cites W1966410796 @default.
• W2012441202 cites W1991615080 @default.
• W2012441202 cites W2009163517 @default.
• W2012441202 cites W2011066367 @default.
• W2012441202 cites W2018781626 @default.
• W2012441202 cites W2021163116 @default.
• W2012441202 cites W2029874047 @default.
• W2012441202 cites W2043759286 @default.
• W2012441202 cites W2047767275 @default.
• W2012441202 cites W2061689271 @default.
• W2012441202 cites W2071968903 @default.
• W2012441202 cites W2079015550 @default.
• W2012441202 cites W2110779213 @default.
• W2012441202 cites W2115706107 @default.
• W2012441202 cites W2116478879 @default.
• W2012441202 cites W2166910723 @default.
• W2012441202 cites W2268904960 @default.
• W2012441202 doi "https://doi.org/10.1152/ajpheart.00701.2004" @default.
• W2012441202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15319200" @default.
• W2012441202 hasPublicationYear "2005" @default.
• W2012441202 type Work @default.
• W2012441202 sameAs 2012441202 @default.
• W2012441202 citedByCount "44" @default.
• W2012441202 countsByYear W20124412022012 @default.
• W2012441202 countsByYear W20124412022013 @default.
• W2012441202 countsByYear W20124412022014 @default.
• W2012441202 countsByYear W20124412022015 @default.
• W2012441202 countsByYear W20124412022017 @default.
• W2012441202 countsByYear W20124412022018 @default.
• W2012441202 countsByYear W20124412022019 @default.
• W2012441202 countsByYear W20124412022020 @default.
• W2012441202 countsByYear W20124412022021 @default.
• W2012441202 countsByYear W20124412022022 @default.
• W2012441202 countsByYear W20124412022023 @default.
• W2012441202 crossrefType "journal-article" @default.
• W2012441202 hasAuthorship W2012441202A5011693177 @default.
• W2012441202 hasAuthorship W2012441202A5011755778 @default.
• W2012441202 hasAuthorship W2012441202A5020263309 @default.
• W2012441202 hasAuthorship W2012441202A5030692703 @default.
• W2012441202 hasAuthorship W2012441202A5032980898 @default.
• W2012441202 hasAuthorship W2012441202A5059297531 @default.
• W2012441202 hasAuthorship W2012441202A5067265472 @default.
• W2012441202 hasAuthorship W2012441202A5081559897 @default.
• W2012441202 hasConcept C126322002 @default.
• W2012441202 hasConcept C134018914 @default.
• W2012441202 hasConcept C164705383 @default.
• W2012441202 hasConcept C178790620 @default.
• W2012441202 hasConcept C185592680 @default.
• W2012441202 hasConcept C2777622882 @default.
• W2012441202 hasConcept C2779676291 @default.
• W2012441202 hasConcept C2779768347 @default.
• W2012441202 hasConcept C42219234 @default.
• W2012441202 hasConcept C519581460 @default.
• W2012441202 hasConcept C540031477 @default.
• W2012441202 hasConcept C541997718 @default.
• W2012441202 hasConcept C555293320 @default.
• W2012441202 hasConcept C71924100 @default.
• W2012441202 hasConcept C7836513 @default.
• W2012441202 hasConceptScore W2012441202C126322002 @default.
• W2012441202 hasConceptScore W2012441202C134018914 @default.
• W2012441202 hasConceptScore W2012441202C164705383 @default.
• W2012441202 hasConceptScore W2012441202C178790620 @default.
• W2012441202 hasConceptScore W2012441202C185592680 @default.
• W2012441202 hasConceptScore W2012441202C2777622882 @default.
• W2012441202 hasConceptScore W2012441202C2779676291 @default.
• W2012441202 hasConceptScore W2012441202C2779768347 @default.
• W2012441202 hasConceptScore W2012441202C42219234 @default.
• W2012441202 hasConceptScore W2012441202C519581460 @default.
• W2012441202 hasConceptScore W2012441202C540031477 @default.
• W2012441202 hasConceptScore W2012441202C541997718 @default.
• W2012441202 hasConceptScore W2012441202C555293320 @default.
• W2012441202 hasConceptScore W2012441202C71924100 @default.
• W2012441202 hasConceptScore W2012441202C7836513 @default.
• W2012441202 hasIssue "1" @default.
• W2012441202 hasLocation W20124412021 @default.
• W2012441202 hasLocation W20124412022 @default.
• W2012441202 hasOpenAccess W2012441202 @default.
• W2012441202 hasPrimaryLocation W20124412021 @default.
• W2012441202 hasRelatedWork W1965002200 @default.
• W2012441202 hasRelatedWork W2008087125 @default.
• W2012441202 hasRelatedWork W2019604928 @default.
• W2012441202 hasRelatedWork W2089295326 @default.
• W2012441202 hasRelatedWork W2093911704 @default.
• W2012441202 hasRelatedWork W2095174320 @default.

• next