FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012443237> ?p ?o ?g. }

• W2012443237 endingPage "158" @default.
• W2012443237 startingPage "151" @default.
• W2012443237 abstract "There is evidence that actions of both progesterone (P) and its metabolite, 5α-pregnane-3α-ol-20-one (3α,5α-THP), are important for sexual behavior of estradiol (E 2 )-primed rodents. Olanzapine, an atypical antipsychotic, dose-dependently increases 3α,5α-THP in the cortex of male rats. These experiments investigated the effects of olanzapine administration on female sexual behavior and progestin concentrations. In Experiment 1, ovariectomized (ovx) rats ( N =128) were primed with estradiol benzoate (EB) at Hour 0 and were administered P (0, 50, 100, or 200 μg sc) at Hour 44 and olanzapine (0.0, 2.5, 5.0, or 10.0 mg/kg ip) at Hour 47. At Hour 48, rats were tested for sexual receptivity with a stimulus male. Administration of 10.0 mg/kg of olanzapine, irrespective of P, significantly increased the occurrence (lordosis quotients, LQs) and the intensity (lordosis ratings, LRs) of lordosis compared to all other dosages. Administration of 2.5 or 5.0 mg/kg of olanzapine, irrespective of P, increased LQs and LRs compared to vehicle administration. Olanzapine without P dose-dependently increased LQs and LRs. As expected, administration of P without olanzapine also dose-dependently increased LQs and LRs. In Experiment 2, ovx rats ( N =44, n =4 per group) received EB (0 or 10 μg sc), P (0 or 200 μg sc), and/or olanzapine (0.0, 2.5, 5.0, or 10.0 mg/kg ip). The same pattern of effects seen for lordosis was observed on progestin concentrations. Whole brain and plasma P and 3α,5α-THP concentrations were increased with olanzapine or P dosing and were greatest with coadministration. Together, these data demonstrate that olanzapine and P have independent effects to increase lordosis, P, and 3α,5α-THP concentrations of adult rats and additive effects in combination, suggesting complimentary mechanisms of action." @default.
• W2012443237 created "2016-06-24" @default.
• W2012443237 creator A5009051197 @default.
• W2012443237 creator A5052362557 @default.
• W2012443237 date "2002-05-01" @default.
• W2012443237 modified "2023-09-25" @default.
• W2012443237 title "Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats" @default.
• W2012443237 cites W1508157020 @default.
• W2012443237 cites W1600161962 @default.
• W2012443237 cites W1973381913 @default.
• W2012443237 cites W1974593629 @default.
• W2012443237 cites W1977309548 @default.
• W2012443237 cites W1978007828 @default.
• W2012443237 cites W1981730561 @default.
• W2012443237 cites W1983592432 @default.
• W2012443237 cites W1986586408 @default.
• W2012443237 cites W1989886426 @default.
• W2012443237 cites W1990106622 @default.
• W2012443237 cites W1992433373 @default.
• W2012443237 cites W1993440020 @default.
• W2012443237 cites W1994913081 @default.
• W2012443237 cites W1995163712 @default.
• W2012443237 cites W1998850723 @default.
• W2012443237 cites W2001984010 @default.
• W2012443237 cites W2002618947 @default.
• W2012443237 cites W2005825980 @default.
• W2012443237 cites W2006646026 @default.
• W2012443237 cites W2014261005 @default.
• W2012443237 cites W2014370769 @default.
• W2012443237 cites W2016329727 @default.
• W2012443237 cites W2018769555 @default.
• W2012443237 cites W2018948493 @default.
• W2012443237 cites W2023944349 @default.
• W2012443237 cites W2025915209 @default.
• W2012443237 cites W2027689472 @default.
• W2012443237 cites W2033322493 @default.
• W2012443237 cites W2037051001 @default.
• W2012443237 cites W2037320198 @default.
• W2012443237 cites W2043795123 @default.
• W2012443237 cites W2045355683 @default.
• W2012443237 cites W2045888428 @default.
• W2012443237 cites W2049419922 @default.
• W2012443237 cites W2062526253 @default.
• W2012443237 cites W2062650600 @default.
• W2012443237 cites W2062710960 @default.
• W2012443237 cites W2067173507 @default.
• W2012443237 cites W2072517364 @default.
• W2012443237 cites W2076404055 @default.
• W2012443237 cites W2078568175 @default.
• W2012443237 cites W2079103153 @default.
• W2012443237 cites W2079361554 @default.
• W2012443237 cites W2083447043 @default.
• W2012443237 cites W2083959772 @default.
• W2012443237 cites W2085391858 @default.
• W2012443237 cites W2085993193 @default.
• W2012443237 cites W2088326458 @default.
• W2012443237 cites W2090388443 @default.
• W2012443237 cites W2123380538 @default.
• W2012443237 cites W2127483997 @default.
• W2012443237 cites W2134195901 @default.
• W2012443237 cites W2163010981 @default.
• W2012443237 cites W2284323937 @default.
• W2012443237 cites W2324379664 @default.
• W2012443237 cites W2614843492 @default.
• W2012443237 doi "https://doi.org/10.1016/s0031-9384(02)00689-3" @default.
• W2012443237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12175598" @default.
• W2012443237 hasPublicationYear "2002" @default.
• W2012443237 type Work @default.
• W2012443237 sameAs 2012443237 @default.
• W2012443237 citedByCount "8" @default.
• W2012443237 crossrefType "journal-article" @default.
• W2012443237 hasAuthorship W2012443237A5009051197 @default.
• W2012443237 hasAuthorship W2012443237A5052362557 @default.
• W2012443237 hasConcept C118552586 @default.
• W2012443237 hasConcept C126322002 @default.
• W2012443237 hasConcept C126838900 @default.
• W2012443237 hasConcept C134018914 @default.
• W2012443237 hasConcept C162156334 @default.
• W2012443237 hasConcept C185592680 @default.
• W2012443237 hasConcept C2776412080 @default.
• W2012443237 hasConcept C2776607906 @default.
• W2012443237 hasConcept C2776619155 @default.
• W2012443237 hasConcept C2776978879 @default.
• W2012443237 hasConcept C2778506572 @default.
• W2012443237 hasConcept C2780626132 @default.
• W2012443237 hasConcept C2780901121 @default.
• W2012443237 hasConcept C2780948584 @default.
• W2012443237 hasConcept C36454342 @default.
• W2012443237 hasConcept C513476851 @default.
• W2012443237 hasConcept C71315377 @default.
• W2012443237 hasConcept C71924100 @default.
• W2012443237 hasConcept C8264082 @default.
• W2012443237 hasConceptScore W2012443237C118552586 @default.
• W2012443237 hasConceptScore W2012443237C126322002 @default.
• W2012443237 hasConceptScore W2012443237C126838900 @default.
• W2012443237 hasConceptScore W2012443237C134018914 @default.
• W2012443237 hasConceptScore W2012443237C162156334 @default.
• W2012443237 hasConceptScore W2012443237C185592680 @default.

• next