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- W2012446421 abstract "The nucleus tractus solitarii (nTS) provides the initial central synaptic relay to peripheral chemoreceptor afferent inputs elicited by changes in oxygen tension. Insofar, the overall cumulative evidence pointing towards the N-methyl-D-aspartate (NMDA) glutamate receptor as the critical receptor underlying the early component of the hypoxic ventilatory response (HVR) is reviewed in detail. In addition, we will present recent findings supporting a role for platelet-derived growth factor (PDGF) beta receptor activation in modulation of the late phase of HVR. This evidence underscores the proposal of a working model for intracellular signaling pathways, downstream to the NMDA glutamate and PDGF-beta receptors in nTS neurons, which may contribute to both the ventilatory characteristics of the acute hypoxic response and to subsequently occurring functional adaptations and synaptic plasticity phenomena." @default.
- W2012446421 created "2016-06-24" @default.
- W2012446421 creator A5023808545 @default.
- W2012446421 creator A5043623030 @default.
- W2012446421 creator A5056799133 @default.
- W2012446421 date "2000-07-01" @default.
- W2012446421 modified "2023-10-11" @default.
- W2012446421 title "Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitarius" @default.
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- W2012446421 doi "https://doi.org/10.1016/s0034-5687(00)00129-8" @default.
- W2012446421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10963776" @default.
- W2012446421 hasPublicationYear "2000" @default.
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