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• W2012454384 abstract "Exposure of neuron-enriched cultures of the embryonic rat cerebral cortex to glutamate (Glu) resulted in a concentration-dependent (EC50=50 μM) increase in the release of lactate dehydrogenase (LDH) into the bathing medium. Glu-induced neurotoxicity appeared to be mediated predominantly by the activation of N-methyl-d-aspartate receptors because its effects were almost completely reversed by 1 μM (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801). The potency of Glu was increased by ca eight-fold (EC50=6 μM) when neuronal cultures were incubated with Glu in the presence of the uptake inhibitor l-trans-pyrrolidine-2,4-dicarboxylate (l-trans-PDC). Increased LDH release was also observed when neuron-enriched cultures were exposed to an ineffective concentration of Glu in the presence of increasing concentrations of l-trans-PDC, moreover, the uptake inhibitor itself became neurotoxic at concentrations above 100 μM. Glu also stimulated the release of LDH from neuron–astrocyte co-cultures in a concentration-dependent manner, however, it was found to be less potent (EC50=200 μM) in these cultures than it was in the neuron-enriched cultures. Incubation of the co-cultures with Glu in the presence of the uptake inhibitor increased the potency of Glu (EC50=100 μM) but to a much lesser extent than that found in neuron-enriched cultures. Cultured astrocytes were found to be resistant to injury by Glu even in the presence of the uptake inhibitor." @default.
• W2012454384 created "2016-06-24" @default.
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• W2012454384 date "1997-02-10" @default.
• W2012454384 modified "2023-09-29" @default.
• W2012454384 title "Glutamate toxicity in neuron-enriched and neuron–astrocyte co-cultures: effect of the glutamate uptake inhibitor ?-trans-pyrrolidine-2,4-dicarboxylate" @default.
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• W2012454384 doi "https://doi.org/10.1016/s0197-0186(96)00092-7" @default.
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