FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012461405> ?p ?o ?g. }

• W2012461405 endingPage "645" @default.
• W2012461405 startingPage "635" @default.
• W2012461405 abstract "In addition to ultraviolet radiation, human skin is also exposed to infrared radiation (IR) from natural sunlight. IR typically increases the skin temperature. This study examined whether or not heat shock-induced ROS stimulates MMPs in keratinocyte HaCaT cells. In HaCaT cells, heat shock was found to increase the intracellular ROS levels, including hydrogen peroxide and superoxide. The heat shock treatment induced MMP-1 and MMP-9, but not MMP-2, at the mRNA and protein levels. Moreover, heat shock caused the rapid activation of the three distinct MAPKs, ERK, JNK, and p38 kinase. The heat shock-induced expression of MMP-1 and MMP-9 was significantly suppressed by a pretreatment with the antioxidant NAC or catalase. On the other hand, SOD inhibited heat shock-induced activity of MMP-9 induction, but not MMP-1. A pretreatment with NAC or catalase, but not SOD, attenuated the phosphorylation of ERK, JNK, and p38 kinase by heat shock. The potential sites of ROS generation by heat shock along with its role in the heat shock-induced expression of MMP-1 and MMP-9 were next analyzed. These results indicate that heat shock-induced ROS is promoted via NADPH oxidase, xanthine oxidase, and mitochondria. Indeed, the NADPH oxidase and xanthine oxidase activities were increased by heat shock. Overall, the ROS produced by heat shock may play an important role in the heat shock-induced activation of MAPKs, which can induce MMP-1 and-9 expressions." @default.
• W2012461405 created "2016-06-24" @default.
• W2012461405 creator A5006437153 @default.
• W2012461405 creator A5014500889 @default.
• W2012461405 creator A5049687242 @default.
• W2012461405 creator A5056846121 @default.
• W2012461405 creator A5078256666 @default.
• W2012461405 creator A5084096570 @default.
• W2012461405 date "2008-02-01" @default.
• W2012461405 modified "2023-10-17" @default.
• W2012461405 title "Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression" @default.
• W2012461405 cites W1955881853 @default.
• W2012461405 cites W1968551238 @default.
• W2012461405 cites W1968574657 @default.
• W2012461405 cites W1976044660 @default.
• W2012461405 cites W1977687557 @default.
• W2012461405 cites W1978537703 @default.
• W2012461405 cites W1980166485 @default.
• W2012461405 cites W1981397830 @default.
• W2012461405 cites W1986010238 @default.
• W2012461405 cites W1988357714 @default.
• W2012461405 cites W1996004246 @default.
• W2012461405 cites W1998473063 @default.
• W2012461405 cites W2001738446 @default.
• W2012461405 cites W2003860066 @default.
• W2012461405 cites W2004997576 @default.
• W2012461405 cites W2007681259 @default.
• W2012461405 cites W2012001366 @default.
• W2012461405 cites W2033146212 @default.
• W2012461405 cites W2044899507 @default.
• W2012461405 cites W2057905199 @default.
• W2012461405 cites W2062507019 @default.
• W2012461405 cites W2063641138 @default.
• W2012461405 cites W2063747608 @default.
• W2012461405 cites W2068982039 @default.
• W2012461405 cites W2070851068 @default.
• W2012461405 cites W2080647590 @default.
• W2012461405 cites W2090125712 @default.
• W2012461405 cites W2090554202 @default.
• W2012461405 cites W2115362310 @default.
• W2012461405 cites W2122111818 @default.
• W2012461405 cites W2141630917 @default.
• W2012461405 cites W2142643911 @default.
• W2012461405 cites W2143464311 @default.
• W2012461405 cites W2156272519 @default.
• W2012461405 cites W2161027243 @default.
• W2012461405 cites W2161901859 @default.
• W2012461405 cites W2198511177 @default.
• W2012461405 cites W2202764688 @default.
• W2012461405 cites W2313226498 @default.
• W2012461405 cites W4241815599 @default.
• W2012461405 doi "https://doi.org/10.1016/j.freeradbiomed.2007.10.053" @default.
• W2012461405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18036352" @default.
• W2012461405 hasPublicationYear "2008" @default.
• W2012461405 type Work @default.
• W2012461405 sameAs 2012461405 @default.
• W2012461405 citedByCount "124" @default.
• W2012461405 countsByYear W20124614052012 @default.
• W2012461405 countsByYear W20124614052013 @default.
• W2012461405 countsByYear W20124614052014 @default.
• W2012461405 countsByYear W20124614052015 @default.
• W2012461405 countsByYear W20124614052016 @default.
• W2012461405 countsByYear W20124614052017 @default.
• W2012461405 countsByYear W20124614052018 @default.
• W2012461405 countsByYear W20124614052019 @default.
• W2012461405 countsByYear W20124614052020 @default.
• W2012461405 countsByYear W20124614052021 @default.
• W2012461405 countsByYear W20124614052022 @default.
• W2012461405 countsByYear W20124614052023 @default.
• W2012461405 crossrefType "journal-article" @default.
• W2012461405 hasAuthorship W2012461405A5006437153 @default.
• W2012461405 hasAuthorship W2012461405A5014500889 @default.
• W2012461405 hasAuthorship W2012461405A5049687242 @default.
• W2012461405 hasAuthorship W2012461405A5056846121 @default.
• W2012461405 hasAuthorship W2012461405A5078256666 @default.
• W2012461405 hasAuthorship W2012461405A5084096570 @default.
• W2012461405 hasConcept C104317684 @default.
• W2012461405 hasConcept C118995209 @default.
• W2012461405 hasConcept C153911025 @default.
• W2012461405 hasConcept C181199279 @default.
• W2012461405 hasConcept C184235292 @default.
• W2012461405 hasConcept C185592680 @default.
• W2012461405 hasConcept C202751555 @default.
• W2012461405 hasConcept C205260736 @default.
• W2012461405 hasConcept C2776151105 @default.
• W2012461405 hasConcept C2778102346 @default.
• W2012461405 hasConcept C2778979269 @default.
• W2012461405 hasConcept C2779719074 @default.
• W2012461405 hasConcept C2780795997 @default.
• W2012461405 hasConcept C48349386 @default.
• W2012461405 hasConcept C51551487 @default.
• W2012461405 hasConcept C55493867 @default.
• W2012461405 hasConcept C86803240 @default.
• W2012461405 hasConcept C95444343 @default.
• W2012461405 hasConcept C97029542 @default.
• W2012461405 hasConceptScore W2012461405C104317684 @default.
• W2012461405 hasConceptScore W2012461405C118995209 @default.
• W2012461405 hasConceptScore W2012461405C153911025 @default.

• next