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• W2012462612 startingPage "155" @default.
• W2012462612 abstract "We investigated the interactions between Compound A (CpdA), an analog of a hydroxyphenyl aziridine precursor found in an African shrub, and the androgen receptor (AR). CpdA represses androgen-induced activation of both specific and non-specific androgen DNA response elements. While a similar effect was obtained for the progesterone receptor (PR) via a non-specific hormone response element, CpdA had no effect on the actions of the glucocorticoid and mineralocorticoid receptors. CpdA represses the ligand-dependent interaction between the NH(2)- and COOH-terminal domains of the AR, similar to well-characterised anti-androgens. CpdA also interferes with the interaction of steroid receptor co-activator 1 (SRC1) with the activation domain AF2 but not with AF1. However, CpdA does not compete with androgen for binding to the AR. These results demonstrate that CpdA elicits anti-androgenic actions by a mechanism other than competitive binding for the AR." @default.
• W2012462612 created "2016-06-24" @default.
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• W2012462612 date "2003-03-01" @default.
• W2012462612 modified "2023-09-30" @default.
• W2012462612 title "Anti-androgenic properties of Compound A, an analog of a non-steroidal plant compound" @default.
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• W2012462612 doi "https://doi.org/10.1016/s0303-7207(02)00411-2" @default.
• W2012462612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12706303" @default.
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