Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012483436> ?p ?o ?g. }
- W2012483436 endingPage "1696" @default.
- W2012483436 startingPage "1689" @default.
- W2012483436 abstract "OBJECTIVE Type 2 diabetes is characterized by insulin resistance, which is involved in the development of Alzheimer disease. This study aims to investigate the relationship between abnormal resting-state brain functional connectivity and insulin resistance in type 2 diabetes. RESEARCH DESIGN AND METHODS A total of 30 patients with type 2 diabetes and 31 healthy well-matched volunteers were prospectively examined. Resting-state brain functional connectivity analysis was used to examine the correlation between the posterior cingulate cortex (PCC) and whole-brain regions. The possible relationships between functional connectivity measures and insulin resistance were evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS Compared with healthy controls, we observed significantly decreased functional connectivity of the PCC within some selected regions, including the right middle temporal gyrus (MTG), left lingual gyrus, left middle occipital gyrus, and left precentral gyrus; increased functional connectivity of the PCC was detected in the left cerebellum posterior lobe, right superior frontal gyrus, and right middle frontal gyrus. A significant negative correlation was found between the PCC-right MTG connectivity and HOMA-IR in type 2 diabetic patients (P = 0.014; r = −0.446). CONCLUSIONS Type 2 diabetic patients develop aberrant functional connectivity of the PCC, which is associated with insulin resistance in selected brain regions. Resting-state connectivity disturbance of PCC–MTG may be a central role for evaluating the cognitive dysfunction in type 2 diabetes." @default.
- W2012483436 created "2016-06-24" @default.
- W2012483436 creator A5004012046 @default.
- W2012483436 creator A5005900235 @default.
- W2012483436 creator A5010089987 @default.
- W2012483436 creator A5011099443 @default.
- W2012483436 creator A5013263658 @default.
- W2012483436 creator A5031466356 @default.
- W2012483436 creator A5046384042 @default.
- W2012483436 creator A5067172872 @default.
- W2012483436 creator A5088596691 @default.
- W2012483436 date "2014-05-10" @default.
- W2012483436 modified "2023-10-16" @default.
- W2012483436 title "Aberrant Brain Functional Connectivity Related to Insulin Resistance in Type 2 Diabetes: A Resting-State fMRI Study" @default.
- W2012483436 cites W1953255974 @default.
- W2012483436 cites W1969227910 @default.
- W2012483436 cites W1976571725 @default.
- W2012483436 cites W1984099286 @default.
- W2012483436 cites W1984623255 @default.
- W2012483436 cites W1985579937 @default.
- W2012483436 cites W1988629934 @default.
- W2012483436 cites W1992431456 @default.
- W2012483436 cites W1998878650 @default.
- W2012483436 cites W1999358054 @default.
- W2012483436 cites W2009494091 @default.
- W2012483436 cites W2011502145 @default.
- W2012483436 cites W2028436804 @default.
- W2012483436 cites W2034348743 @default.
- W2012483436 cites W2035825704 @default.
- W2012483436 cites W2048288736 @default.
- W2012483436 cites W2066669089 @default.
- W2012483436 cites W2066898102 @default.
- W2012483436 cites W2070663429 @default.
- W2012483436 cites W2072740695 @default.
- W2012483436 cites W2080847728 @default.
- W2012483436 cites W2084979315 @default.
- W2012483436 cites W2097164682 @default.
- W2012483436 cites W2111783629 @default.
- W2012483436 cites W2118331240 @default.
- W2012483436 cites W2120447295 @default.
- W2012483436 cites W2121399513 @default.
- W2012483436 cites W2121483283 @default.
- W2012483436 cites W2131943911 @default.
- W2012483436 cites W2133450205 @default.
- W2012483436 cites W2133941851 @default.
- W2012483436 cites W2137566817 @default.
- W2012483436 cites W2162010696 @default.
- W2012483436 cites W2164418602 @default.
- W2012483436 doi "https://doi.org/10.2337/dc13-2127" @default.
- W2012483436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24658392" @default.
- W2012483436 hasPublicationYear "2014" @default.
- W2012483436 type Work @default.
- W2012483436 sameAs 2012483436 @default.
- W2012483436 citedByCount "100" @default.
- W2012483436 countsByYear W20124834362014 @default.
- W2012483436 countsByYear W20124834362015 @default.
- W2012483436 countsByYear W20124834362016 @default.
- W2012483436 countsByYear W20124834362017 @default.
- W2012483436 countsByYear W20124834362018 @default.
- W2012483436 countsByYear W20124834362019 @default.
- W2012483436 countsByYear W20124834362020 @default.
- W2012483436 countsByYear W20124834362021 @default.
- W2012483436 countsByYear W20124834362022 @default.
- W2012483436 countsByYear W20124834362023 @default.
- W2012483436 crossrefType "journal-article" @default.
- W2012483436 hasAuthorship W2012483436A5004012046 @default.
- W2012483436 hasAuthorship W2012483436A5005900235 @default.
- W2012483436 hasAuthorship W2012483436A5010089987 @default.
- W2012483436 hasAuthorship W2012483436A5011099443 @default.
- W2012483436 hasAuthorship W2012483436A5013263658 @default.
- W2012483436 hasAuthorship W2012483436A5031466356 @default.
- W2012483436 hasAuthorship W2012483436A5046384042 @default.
- W2012483436 hasAuthorship W2012483436A5067172872 @default.
- W2012483436 hasAuthorship W2012483436A5088596691 @default.
- W2012483436 hasBestOaLocation W20124834361 @default.
- W2012483436 hasConcept C118552586 @default.
- W2012483436 hasConcept C126322002 @default.
- W2012483436 hasConcept C126838900 @default.
- W2012483436 hasConcept C134018914 @default.
- W2012483436 hasConcept C15744967 @default.
- W2012483436 hasConcept C169760540 @default.
- W2012483436 hasConcept C169900460 @default.
- W2012483436 hasConcept C2775956885 @default.
- W2012483436 hasConcept C2777180221 @default.
- W2012483436 hasConcept C2777391703 @default.
- W2012483436 hasConcept C2778733324 @default.
- W2012483436 hasConcept C2779306644 @default.
- W2012483436 hasConcept C2779991468 @default.
- W2012483436 hasConcept C2780621315 @default.
- W2012483436 hasConcept C2781449700 @default.
- W2012483436 hasConcept C3018011982 @default.
- W2012483436 hasConcept C555293320 @default.
- W2012483436 hasConcept C66324658 @default.
- W2012483436 hasConcept C71924100 @default.
- W2012483436 hasConceptScore W2012483436C118552586 @default.
- W2012483436 hasConceptScore W2012483436C126322002 @default.
- W2012483436 hasConceptScore W2012483436C126838900 @default.
- W2012483436 hasConceptScore W2012483436C134018914 @default.