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• W2012486988 abstract "1. The pharmacokinetics of 6,7-dimethoxy 4-(p-chlorobenzyl) isoquinoline (PV2) in mouse and rat show that it is 52% absorbed after oral administration and undergoes a marked hepatic first-pass effect (83%).2. Tissue distribution shows an affinity for the aorta, cardiac tissues and cerebral blood vessels.3. It is excreted in the urine (20% dose) and faeces (70%); biliary excretion is high (80% dose).4. It is metabolized mainly by O-demethylation to 6- and 7-desmethyl-PV 2 and 6,7-didesmethyl-PV 2, as well as to six other non-identified metabolites." @default.
• W2012486988 created "2016-06-24" @default.
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• W2012486988 date "1985-01-01" @default.
• W2012486988 modified "2023-09-27" @default.
• W2012486988 title "Metabolism of 6,7-dimethoxy 4-(<i>p</i>-chlorobenzyl)-isoquinoline. I. Single-dose pharmacokinetics in the rat and mouse" @default.
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• W2012486988 doi "https://doi.org/10.3109/00498258509045885" @default.
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