Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012488173> ?p ?o ?g. }
- W2012488173 endingPage "e60818" @default.
- W2012488173 startingPage "e60818" @default.
- W2012488173 abstract "Antimicrobial peptides (AMPs) isolated from several organisms have been receiving much attention due to some specific features that allow them to interact with, bind to, and disrupt cell membranes. The aim of this paper was to study the interactions between a membrane mimetic and the cationic AMP Ctx(Ile(21))-Ha as well as analogues containing the paramagnetic amino acid 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) incorporated at residue positions n = 0, 2, and 13. Circular dichroism studies showed that the peptides, except for [TOAC(13)]Ctx(Ile(21))-Ha, are unstructured in aqueous solution but acquire different amounts of α-helical secondary structure in the presence of trifluorethanol and lysophosphocholine micelles. Fluorescence experiments indicated that all peptides were able to interact with LPC micelles. In addition, Ctx(Ile(21))-Ha and [TOAC(13)]Ctx(Ile(21))-Ha peptides presented similar water accessibility for the Trp residue located near the N-terminal sequence. Electron spin resonance experiments showed two spectral components for [TOAC(0)]Ctx(Ile(21))-Ha, which are most likely due to two membrane-bound peptide conformations. In contrast, TOAC(2) and TOAC(13) derivatives presented a single spectral component corresponding to a strong immobilization of the probe. Thus, our findings allowed the description of the peptide topology in the membrane mimetic, where the N-terminal region is in dynamic equilibrium between an ordered, membrane-bound conformation and a disordered, mobile conformation; position 2 is most likely situated in the lipid polar head group region, and residue 13 is fully inserted into the hydrophobic core of the membrane." @default.
- W2012488173 created "2016-06-24" @default.
- W2012488173 creator A5025672464 @default.
- W2012488173 creator A5036602513 @default.
- W2012488173 creator A5058201358 @default.
- W2012488173 creator A5061421413 @default.
- W2012488173 creator A5062467240 @default.
- W2012488173 creator A5082135925 @default.
- W2012488173 creator A5087935552 @default.
- W2012488173 creator A5049092238 @default.
- W2012488173 date "2013-04-09" @default.
- W2012488173 modified "2023-10-10" @default.
- W2012488173 title "Dynamics and Conformational Studies of TOAC Spin Labeled Analogues of Ctx(Ile21)-Ha Peptide from Hypsiboas albopunctatus" @default.
- W2012488173 cites W1508686080 @default.
- W2012488173 cites W1964981541 @default.
- W2012488173 cites W1966258770 @default.
- W2012488173 cites W1966582094 @default.
- W2012488173 cites W1970587774 @default.
- W2012488173 cites W1974682560 @default.
- W2012488173 cites W1975775428 @default.
- W2012488173 cites W1979233985 @default.
- W2012488173 cites W1983371465 @default.
- W2012488173 cites W1989452309 @default.
- W2012488173 cites W1989477610 @default.
- W2012488173 cites W1990264812 @default.
- W2012488173 cites W1991555945 @default.
- W2012488173 cites W1997820347 @default.
- W2012488173 cites W1998862380 @default.
- W2012488173 cites W2001189584 @default.
- W2012488173 cites W2002195659 @default.
- W2012488173 cites W2007886107 @default.
- W2012488173 cites W2008812223 @default.
- W2012488173 cites W2009106357 @default.
- W2012488173 cites W2010316556 @default.
- W2012488173 cites W2012567536 @default.
- W2012488173 cites W2016527928 @default.
- W2012488173 cites W2017039511 @default.
- W2012488173 cites W2025938842 @default.
- W2012488173 cites W2028324490 @default.
- W2012488173 cites W2028869026 @default.
- W2012488173 cites W2029343676 @default.
- W2012488173 cites W2039340379 @default.
- W2012488173 cites W2042334208 @default.
- W2012488173 cites W2054083129 @default.
- W2012488173 cites W2054602599 @default.
- W2012488173 cites W2058293875 @default.
- W2012488173 cites W2060728272 @default.
- W2012488173 cites W2072833879 @default.
- W2012488173 cites W2074042037 @default.
- W2012488173 cites W2074970514 @default.
- W2012488173 cites W2075942433 @default.
- W2012488173 cites W2079071013 @default.
- W2012488173 cites W2079336965 @default.
- W2012488173 cites W2080800640 @default.
- W2012488173 cites W2083835441 @default.
- W2012488173 cites W2084701672 @default.
- W2012488173 cites W2084728430 @default.
- W2012488173 cites W2087125825 @default.
- W2012488173 cites W2088177059 @default.
- W2012488173 cites W2089146877 @default.
- W2012488173 cites W2090342172 @default.
- W2012488173 cites W2095699986 @default.
- W2012488173 cites W2115886057 @default.
- W2012488173 cites W2128677332 @default.
- W2012488173 cites W2128768386 @default.
- W2012488173 cites W2133056039 @default.
- W2012488173 cites W2134388671 @default.
- W2012488173 cites W2134661315 @default.
- W2012488173 cites W2139754101 @default.
- W2012488173 cites W2153947022 @default.
- W2012488173 cites W2158482458 @default.
- W2012488173 cites W2160780417 @default.
- W2012488173 cites W2161192268 @default.
- W2012488173 cites W93670665 @default.
- W2012488173 doi "https://doi.org/10.1371/journal.pone.0060818" @default.
- W2012488173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621989" @default.
- W2012488173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23585852" @default.
- W2012488173 hasPublicationYear "2013" @default.
- W2012488173 type Work @default.
- W2012488173 sameAs 2012488173 @default.
- W2012488173 citedByCount "28" @default.
- W2012488173 countsByYear W20124881732014 @default.
- W2012488173 countsByYear W20124881732015 @default.
- W2012488173 countsByYear W20124881732016 @default.
- W2012488173 countsByYear W20124881732017 @default.
- W2012488173 countsByYear W20124881732018 @default.
- W2012488173 countsByYear W20124881732020 @default.
- W2012488173 countsByYear W20124881732021 @default.
- W2012488173 countsByYear W20124881732022 @default.
- W2012488173 countsByYear W20124881732023 @default.
- W2012488173 crossrefType "journal-article" @default.
- W2012488173 hasAuthorship W2012488173A5025672464 @default.
- W2012488173 hasAuthorship W2012488173A5036602513 @default.
- W2012488173 hasAuthorship W2012488173A5049092238 @default.
- W2012488173 hasAuthorship W2012488173A5058201358 @default.
- W2012488173 hasAuthorship W2012488173A5061421413 @default.
- W2012488173 hasAuthorship W2012488173A5062467240 @default.
- W2012488173 hasAuthorship W2012488173A5082135925 @default.