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• W2012499260 abstract "A method for determining cis-diamminedichloroplatinum(II) (CDDP), an anticancer drug, in plasma and urine by HPLC with UV detection and column-switching has been developed. Typical conditions were as follows. An apparatus was composed of two columns, two pumps, a UV detector, a sample injector with a 100 μL loop, a switching valve, a column oven and a recorder. A Rheodyne model 7125 sample injector was used as the switching valve. A precolumn (4.6 mm ID × 25 cm) was packed with MCI GEL CK10S (a strong cation exchanger), and an analytical column (4.6 mm ID × 5 cm) was packed with MCI GEL CDR10 (a strong anion exchanger). Both columns were connected in series via the switching valve. The CDDP-containing fraction of the effluent from the precolumn was loaded to the analytical column by column-switching and the effluent from the analytical column was monitored at 210 nm. An eluent of 0.3 M sodium dihydrogen phosphate was pumped at a flow rate of 1 mL/min and the columns were maintained at 40°C. CDDP was eluted at about 11 min and the identity of the peak of CDDP on the chromatogram was confirmed by its 3-dimensional chromatogram and analysis of platinum in the column effluent. Under the conditions described above, a linear relationship was obtained between peak height and concentration of CDDP up to 100 μM. Correlation efficients were 0.998 for plasma and 0.999 for urine. The detection limit was 0.1 μM for CDDP in both plasma and urine (S/N = 3, 0.005 AUFS). The reproducibility was within 3% for 10 determinations. The CDDP concentrations in plasma and urine of a patient with ovarian carcinoma receiving CDDP treatment could be determined." @default.
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• W2012499260 date "1989-01-01" @default.
• W2012499260 modified "2023-10-17" @default.
• W2012499260 title "HPLC determination ofcis-diamminedichloroplatinum(II) in plasma and urine with UV detection and column-switching" @default.
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• W2012499260 doi "https://doi.org/10.1002/bmc.1130030105" @default.
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