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• W2012502505 abstract "The mitotic spindle is a complex and dynamic structure. Although much has been learned about how spindles assemble and mediate chromosome segregation, how spindles rapidly and irreversibly disassemble during telophase is less clear. We used synthetic lethal screens in budding yeast to identify mutants defective in spindle disassembly. Real-time, live cell imaging analysis of spindle disassembly was performed on nine mutants defective in this process. Results of this analysis suggest that spindle disassembly is achieved by mechanistically distinct but functionally overlapping subprocesses: disengagement of the spindle halves, arrest of spindle elongation, and initiation of interpolar microtubule depolymerization. These subprocesses are largely governed by the anaphase-promoting complex, Aurora B kinase, and kinesin-8. Combinatorial inhibition of these subprocesses yielded cells with hyperstable spindle remnants and dramatic defects in cell cycle progression, establishing that rapid spindle disassembly is crucial for cell proliferation." @default.
• W2012502505 created "2016-06-24" @default.
• W2012502505 creator A5053118413 @default.
• W2012502505 creator A5061998778 @default.
• W2012502505 creator A5067644278 @default.
• W2012502505 date "2010-11-15" @default.
• W2012502505 modified "2023-10-13" @default.
• W2012502505 title "Mitotic spindle disassembly occurs via distinct subprocesses driven by the anaphase-promoting complex, Aurora B kinase, and kinesin-8" @default.
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• W2012502505 doi "https://doi.org/10.1083/jcb.201006028" @default.
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