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- W2012503411 abstract "The innate immune system is the body’s first line of defense against invading pathogens and is responsible for recognizing and responding to the general structural patterns exhibited by pathogens, commonly known as pathogen-associated molecular patterns (PAMPs) and microbial-associated molecular patterns (MAMPs). The innate immune receptors responsible for recognizing PAMPs/MAMPs are known as pattern recognition receptors (PRRs) and offer general protection to the host. Mutations to PRRs such as nucleotide-binding oligomerization domain-containing protein 2 (NOD2), can lead to a misregulated immune system and a variety of diseases, including Crohn’s disease. In this chapter we discuss the role of the innate immune receptor NOD2 in Crohn’s disease pathogenesis, key observations that contribute to a better understanding of the disease, and how these observations can be used to improve diagnosis and potential therapies for patients." @default.
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- W2012503411 date "1981-11-01" @default.
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- W2012503411 title "The chemical modification of the C-2 substituent in the sugar moiety of N-acetylmuramoyl-l-alanyl-d-isoglutamine, and the immunoadjuvant activities" @default.
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- W2012503411 doi "https://doi.org/10.1016/s0008-6215(00)80680-1" @default.
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