Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012504003> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2012504003 endingPage "61" @default.
- W2012504003 startingPage "49" @default.
- W2012504003 abstract "AmBisome is a lyophilizcd preparation of lipaomal amphotericin B. The acute intravenous toxicity of AmBisome was evaluated in mice and rats; and the LD50s were found to be > 175 and 50 mg/kg, respectively. The corresponding LD50 for conventional amphotericin B were approximately 2·3 and 1·6 mg/kg for mice and rats, respectively. The multiple dose toxicity test confirmed that AmBisome was well tolerated by both spocies. There were no deaths observed among mia receiving 25 or 50 mg/kg AmBisome for 14 days, and only two deaths among mice receiving 75 mg/kg AmBisome. One rat died in the group receiving 25 mg/kg AmBisome for 30 days. However, five of ten and nine of ten rats died in the groups treated with 50 and 75 mg/kg AmBisome, respectively. Hepatotoxicity was evident by elevation in serum liver enzyme levels for thesc groups. Initial pharmacokinetic evaluations demonstrated that peak plasma conentrations of 87 and 118 mg/kg, respectively, were attained in mice and rats after injection with 5 mg/kg AmBisome. Terminal plasma half-lives of 3·36 and 7·56 h were calculated for mice and rats, respectively.Tissue accumulations of amphotericin B resulting from multiple dose intravenous administration of either conventional amphotericin B or ArnBisome were determined. At equivalent doses of 1 mg/kg, AmBisome treatment resulted in higher liver and spleen uptake of drug, but lower kidney and lung uptake than amphotericin B.At 5 mg/kg, AmBisome treatment resulted in conantrations of drug in the kidney and lungs that were comparable to corresponding tissue levels obsevered in the group treated with 1 mg/kg conventional amphoterian B. However, liver and spleen conantrations were more than ten-fold greater relative to the group treated with 1 mg/kg conventional drug. The 5 mg/kg AmBisome treatment also resulted in a low, but measurable accumulation of amphotericin B in brain tissue. The results show that the AmBisome formulation has greatly reduced the toxicity of amphotericin B, and high plasma concentrations and tissue accumulations of drug can be achieved with non-toxic doses of AmBisome." @default.
- W2012504003 created "2016-06-24" @default.
- W2012504003 creator A5008669277 @default.
- W2012504003 creator A5012281370 @default.
- W2012504003 creator A5039854206 @default.
- W2012504003 creator A5040931219 @default.
- W2012504003 creator A5067420461 @default.
- W2012504003 date "1991-01-01" @default.
- W2012504003 modified "2023-10-12" @default.
- W2012504003 title "Pharmacology and toxicology of a liposomal formulation of amphotericin B (AmBisome) in rodents" @default.
- W2012504003 cites W1534854046 @default.
- W2012504003 cites W1554437088 @default.
- W2012504003 cites W1971226006 @default.
- W2012504003 cites W1983745724 @default.
- W2012504003 cites W1984391575 @default.
- W2012504003 cites W2020358599 @default.
- W2012504003 cites W2023916811 @default.
- W2012504003 cites W2035920335 @default.
- W2012504003 cites W2037587995 @default.
- W2012504003 cites W2038225831 @default.
- W2012504003 cites W2075571283 @default.
- W2012504003 cites W2093627967 @default.
- W2012504003 cites W2128429409 @default.
- W2012504003 cites W2129309504 @default.
- W2012504003 cites W2131401212 @default.
- W2012504003 cites W2149561805 @default.
- W2012504003 cites W2156730883 @default.
- W2012504003 cites W2165692316 @default.
- W2012504003 cites W2317369582 @default.
- W2012504003 cites W2333783772 @default.
- W2012504003 cites W40339816 @default.
- W2012504003 doi "https://doi.org/10.1093/jac/28.suppl_b.49" @default.
- W2012504003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1778892" @default.
- W2012504003 hasPublicationYear "1991" @default.
- W2012504003 type Work @default.
- W2012504003 sameAs 2012504003 @default.
- W2012504003 citedByCount "191" @default.
- W2012504003 countsByYear W20125040032012 @default.
- W2012504003 countsByYear W20125040032013 @default.
- W2012504003 countsByYear W20125040032014 @default.
- W2012504003 countsByYear W20125040032015 @default.
- W2012504003 countsByYear W20125040032016 @default.
- W2012504003 countsByYear W20125040032017 @default.
- W2012504003 countsByYear W20125040032018 @default.
- W2012504003 countsByYear W20125040032019 @default.
- W2012504003 countsByYear W20125040032020 @default.
- W2012504003 countsByYear W20125040032022 @default.
- W2012504003 countsByYear W20125040032023 @default.
- W2012504003 crossrefType "journal-article" @default.
- W2012504003 hasAuthorship W2012504003A5008669277 @default.
- W2012504003 hasAuthorship W2012504003A5012281370 @default.
- W2012504003 hasAuthorship W2012504003A5039854206 @default.
- W2012504003 hasAuthorship W2012504003A5040931219 @default.
- W2012504003 hasAuthorship W2012504003A5067420461 @default.
- W2012504003 hasConcept C112705442 @default.
- W2012504003 hasConcept C126322002 @default.
- W2012504003 hasConcept C16005928 @default.
- W2012504003 hasConcept C2776694085 @default.
- W2012504003 hasConcept C2779548794 @default.
- W2012504003 hasConcept C2779629538 @default.
- W2012504003 hasConcept C2780035454 @default.
- W2012504003 hasConcept C2780091579 @default.
- W2012504003 hasConcept C2780931953 @default.
- W2012504003 hasConcept C29730261 @default.
- W2012504003 hasConcept C71924100 @default.
- W2012504003 hasConcept C98274493 @default.
- W2012504003 hasConceptScore W2012504003C112705442 @default.
- W2012504003 hasConceptScore W2012504003C126322002 @default.
- W2012504003 hasConceptScore W2012504003C16005928 @default.
- W2012504003 hasConceptScore W2012504003C2776694085 @default.
- W2012504003 hasConceptScore W2012504003C2779548794 @default.
- W2012504003 hasConceptScore W2012504003C2779629538 @default.
- W2012504003 hasConceptScore W2012504003C2780035454 @default.
- W2012504003 hasConceptScore W2012504003C2780091579 @default.
- W2012504003 hasConceptScore W2012504003C2780931953 @default.
- W2012504003 hasConceptScore W2012504003C29730261 @default.
- W2012504003 hasConceptScore W2012504003C71924100 @default.
- W2012504003 hasConceptScore W2012504003C98274493 @default.
- W2012504003 hasIssue "suppl B" @default.
- W2012504003 hasLocation W20125040031 @default.
- W2012504003 hasLocation W20125040032 @default.
- W2012504003 hasOpenAccess W2012504003 @default.
- W2012504003 hasPrimaryLocation W20125040031 @default.
- W2012504003 hasRelatedWork W2049784275 @default.
- W2012504003 hasRelatedWork W2112365888 @default.
- W2012504003 hasRelatedWork W2145947441 @default.
- W2012504003 hasRelatedWork W2162912313 @default.
- W2012504003 hasRelatedWork W2349963000 @default.
- W2012504003 hasRelatedWork W2352350815 @default.
- W2012504003 hasRelatedWork W2354402740 @default.
- W2012504003 hasRelatedWork W2356107634 @default.
- W2012504003 hasRelatedWork W2390083128 @default.
- W2012504003 hasRelatedWork W2991030316 @default.
- W2012504003 hasVolume "28" @default.
- W2012504003 isParatext "false" @default.
- W2012504003 isRetracted "false" @default.
- W2012504003 magId "2012504003" @default.
- W2012504003 workType "article" @default.