FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012504595> ?p ?o ?g. }

• W2012504595 endingPage "12252" @default.
• W2012504595 startingPage "12244" @default.
• W2012504595 abstract "The CXCL1/CXCR2 axis plays a crucial role in recruiting neutrophils in response to microbial infection and tissue injury, and dysfunction in this process has been implicated in various inflammatory diseases. Chemokines exist as monomers and dimers, and compelling evidence now exists that both forms regulate in vivo function. Therefore, knowledge of the receptor activities of both CXCL1 monomer and dimer is essential to describe the molecular mechanisms by which they orchestrate neutrophil function. The monomer-dimer equilibrium constant (~20 μm) and the CXCR2 binding constant (1 nm) indicate that WT CXCL1 is active as a monomer. To characterize dimer activity, we generated a trapped dimer by introducing a disulfide across the dimer interface. This disulfide-linked CXCL1 dimer binds CXCR2 with nanomolar affinity and shows potent agonist activity in various cellular assays. We also compared the receptor binding mechanism of this dimer with that of a CXCL1 monomer, generated by deleting the C-terminal residues that stabilize the dimer interface. We observe that the binding interactions of the dimer and monomer to the CXCR2 N-terminal domain, which plays an important role in determining affinity and activity, are essentially conserved. The potent activity of the CXCL1 dimer is novel: dimers of the CC chemokines CCL2 and CCL4 are inactive, and the dimer of the CXC chemokine CXCL8 (which is closely related to CXCL1) is marginally active for CXCR1 but shows variable activity for CXCR2. We conclude that large differences in dimer activity among different chemokine-receptor pairs have evolved for fine-tuned leukocyte function." @default.
• W2012504595 created "2016-06-24" @default.
• W2012504595 creator A5023260898 @default.
• W2012504595 creator A5066652800 @default.
• W2012504595 creator A5071880479 @default.
• W2012504595 creator A5082127080 @default.
• W2012504595 creator A5090092577 @default.
• W2012504595 date "2013-04-01" @default.
• W2012504595 modified "2023-10-16" @default.
• W2012504595 title "Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor" @default.
• W2012504595 cites W1554512406 @default.
• W2012504595 cites W1916108665 @default.
• W2012504595 cites W1963479874 @default.
• W2012504595 cites W1964083898 @default.
• W2012504595 cites W1968177960 @default.
• W2012504595 cites W1979783975 @default.
• W2012504595 cites W1987324930 @default.
• W2012504595 cites W1995806978 @default.
• W2012504595 cites W1996857712 @default.
• W2012504595 cites W1997850410 @default.
• W2012504595 cites W1998203652 @default.
• W2012504595 cites W2004926819 @default.
• W2012504595 cites W2008761606 @default.
• W2012504595 cites W2010239869 @default.
• W2012504595 cites W2012784541 @default.
• W2012504595 cites W2014204673 @default.
• W2012504595 cites W2020672482 @default.
• W2012504595 cites W2022481460 @default.
• W2012504595 cites W2026605479 @default.
• W2012504595 cites W2028304773 @default.
• W2012504595 cites W2034299708 @default.
• W2012504595 cites W2037460653 @default.
• W2012504595 cites W2046927449 @default.
• W2012504595 cites W2051330539 @default.
• W2012504595 cites W2053033209 @default.
• W2012504595 cites W2053039244 @default.
• W2012504595 cites W2053945938 @default.
• W2012504595 cites W2057223279 @default.
• W2012504595 cites W2061814831 @default.
• W2012504595 cites W2077902112 @default.
• W2012504595 cites W2080411666 @default.
• W2012504595 cites W2082176639 @default.
• W2012504595 cites W2089062549 @default.
• W2012504595 cites W2097897519 @default.
• W2012504595 cites W2104918497 @default.
• W2012504595 cites W2126897659 @default.
• W2012504595 cites W2132674776 @default.
• W2012504595 cites W2152853006 @default.
• W2012504595 cites W2153828473 @default.
• W2012504595 cites W2155728143 @default.
• W2012504595 cites W2160914594 @default.
• W2012504595 cites W2163065862 @default.
• W2012504595 cites W2164979145 @default.
• W2012504595 cites W2169821755 @default.
• W2012504595 cites W2293941357 @default.
• W2012504595 cites W4243387284 @default.
• W2012504595 cites W2055124352 @default.
• W2012504595 doi "https://doi.org/10.1074/jbc.m112.443762" @default.
• W2012504595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3636908" @default.
• W2012504595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23479735" @default.
• W2012504595 hasPublicationYear "2013" @default.
• W2012504595 type Work @default.
• W2012504595 sameAs 2012504595 @default.
• W2012504595 citedByCount "50" @default.
• W2012504595 countsByYear W20125045952013 @default.
• W2012504595 countsByYear W20125045952014 @default.
• W2012504595 countsByYear W20125045952015 @default.
• W2012504595 countsByYear W20125045952016 @default.
• W2012504595 countsByYear W20125045952017 @default.
• W2012504595 countsByYear W20125045952018 @default.
• W2012504595 countsByYear W20125045952019 @default.
• W2012504595 countsByYear W20125045952020 @default.
• W2012504595 countsByYear W20125045952021 @default.
• W2012504595 countsByYear W20125045952022 @default.
• W2012504595 countsByYear W20125045952023 @default.
• W2012504595 crossrefType "journal-article" @default.
• W2012504595 hasAuthorship W2012504595A5023260898 @default.
• W2012504595 hasAuthorship W2012504595A5066652800 @default.
• W2012504595 hasAuthorship W2012504595A5071880479 @default.
• W2012504595 hasAuthorship W2012504595A5082127080 @default.
• W2012504595 hasAuthorship W2012504595A5090092577 @default.
• W2012504595 hasBestOaLocation W20125045951 @default.
• W2012504595 hasConcept C12554922 @default.
• W2012504595 hasConcept C12823836 @default.
• W2012504595 hasConcept C13373296 @default.
• W2012504595 hasConcept C170493617 @default.
• W2012504595 hasConcept C178790620 @default.
• W2012504595 hasConcept C185592680 @default.
• W2012504595 hasConcept C2778938600 @default.
• W2012504595 hasConcept C2779546866 @default.
• W2012504595 hasConcept C55493867 @default.
• W2012504595 hasConcept C71240020 @default.
• W2012504595 hasConcept C84913492 @default.
• W2012504595 hasConcept C86803240 @default.
• W2012504595 hasConcept C96525457 @default.
• W2012504595 hasConceptScore W2012504595C12554922 @default.
• W2012504595 hasConceptScore W2012504595C12823836 @default.
• W2012504595 hasConceptScore W2012504595C13373296 @default.

• next