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- W2012505902 abstract "Die Synthese des unsymmetrischen Disulfids 1 [B 15 — 27(Ala 27) — A 19 — 21], eines Ausschnitts aus der aktiven Insulinregion, wird beschrieben. Hiervon ausgehend wird durch Aufbau der Disulfide B 15-27 (Ala 27)-A 20-21, B 15-20-A 19-21, B 15-27 (SEt 19, Ala 27) und [B 15-27 (Ala 27)]2 (2-5) die Primärstruktur schrittweise vereinfacht. Die Herstellung der entsprechenden Disulfidbindungen erfolgte hierbei durch säurekatalysierten Disulfidaustausch zwischen den beiden Teilkomponenten mit SEt-geschützten Cysteinfunktionen. Die dargestellten Cystinpeptidea) weisen eindeutige, jedoch um den Faktor 10−3 bis 10−4 reduzierte Insulinwirkungen auf. Synthesis of Cystine Peptides with a Primary Structure Related to the Active Region of Insulin The synthesis of the unsymmetrical disulfide 1 [B 15-27(Ala 27)-A 19-21], a section of the active insulin region, is described. Starting from this material, stepwise simplification of the primary structure was performed by preparing the disulfides B 15-27 (Ala 27)-A 20-21, B 15-20-A 19-21, B 15-27 (SEt 19, Ala 27), and [B 15-27 (Ala 27)]2 (2-5). The corresponding disulfide bonds were established by proton catalysed disulfide exchange between the two partial components containing SEt-protected cysteine functions. The synthesized cystine peptides exhibit distinct but by the factor of 10−3 to 10−4 reduced insulin activities." @default.
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- W2012505902 date "1981-01-30" @default.
- W2012505902 modified "2023-10-16" @default.
- W2012505902 title "Synthese von Cystinpeptiden mit einer der aktiven Region des Insulins angenäherten Primärstruktur" @default.
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- W2012505902 doi "https://doi.org/10.1002/jlac.198119810121" @default.
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