Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012506704> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012506704 endingPage "142" @default.
- W2012506704 startingPage "139" @default.
- W2012506704 abstract "The solution-phase syntheses of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids were accomplished from dimethyl 3-chloromethylisoxazole-4,5-dicarboxylate by selective nucleophilic chemistry. For example, treatment of this trifunctionalized core with 3-bromobenzylamine and subsequent X-ray analysis identified the sole product as methyl 5-(3-bromobenzylcarbamoyl)-3-chloromethylisoxazole-4-carboxylate. Subjecting this amide/ester to thiophenol in the presence of 1 N NaOH completed the two-step transformation of this versatile starting material to the targeted 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acid. Employing various amines and thiophenols, this chemistry was applied in the generation of a 90-compound library of druglike isoxazoles." @default.
- W2012506704 created "2016-06-24" @default.
- W2012506704 creator A5000777724 @default.
- W2012506704 creator A5002153833 @default.
- W2012506704 creator A5073614733 @default.
- W2012506704 creator A5062624181 @default.
- W2012506704 date "2006-11-30" @default.
- W2012506704 modified "2023-09-27" @default.
- W2012506704 title "Selective Nucleophilic Chemistry in the Synthesis of 5-Carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic Acids" @default.
- W2012506704 cites W1608885177 @default.
- W2012506704 cites W1964095007 @default.
- W2012506704 cites W1988205196 @default.
- W2012506704 cites W2003934266 @default.
- W2012506704 cites W2007980582 @default.
- W2012506704 cites W2058695493 @default.
- W2012506704 cites W2148284063 @default.
- W2012506704 cites W2159503225 @default.
- W2012506704 cites W2170526559 @default.
- W2012506704 cites W2950342377 @default.
- W2012506704 cites W2952126382 @default.
- W2012506704 doi "https://doi.org/10.1021/cc0601074" @default.
- W2012506704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17206842" @default.
- W2012506704 hasPublicationYear "2006" @default.
- W2012506704 type Work @default.
- W2012506704 sameAs 2012506704 @default.
- W2012506704 citedByCount "9" @default.
- W2012506704 countsByYear W20125067042012 @default.
- W2012506704 countsByYear W20125067042013 @default.
- W2012506704 countsByYear W20125067042015 @default.
- W2012506704 countsByYear W20125067042018 @default.
- W2012506704 countsByYear W20125067042022 @default.
- W2012506704 crossrefType "journal-article" @default.
- W2012506704 hasAuthorship W2012506704A5000777724 @default.
- W2012506704 hasAuthorship W2012506704A5002153833 @default.
- W2012506704 hasAuthorship W2012506704A5062624181 @default.
- W2012506704 hasAuthorship W2012506704A5073614733 @default.
- W2012506704 hasConcept C155647269 @default.
- W2012506704 hasConcept C161790260 @default.
- W2012506704 hasConcept C178790620 @default.
- W2012506704 hasConcept C178907741 @default.
- W2012506704 hasConcept C185592680 @default.
- W2012506704 hasConcept C21951064 @default.
- W2012506704 hasConcept C2778074193 @default.
- W2012506704 hasConcept C2778439535 @default.
- W2012506704 hasConcept C2779074116 @default.
- W2012506704 hasConcept C2779801612 @default.
- W2012506704 hasConcept C71240020 @default.
- W2012506704 hasConcept C94412978 @default.
- W2012506704 hasConceptScore W2012506704C155647269 @default.
- W2012506704 hasConceptScore W2012506704C161790260 @default.
- W2012506704 hasConceptScore W2012506704C178790620 @default.
- W2012506704 hasConceptScore W2012506704C178907741 @default.
- W2012506704 hasConceptScore W2012506704C185592680 @default.
- W2012506704 hasConceptScore W2012506704C21951064 @default.
- W2012506704 hasConceptScore W2012506704C2778074193 @default.
- W2012506704 hasConceptScore W2012506704C2778439535 @default.
- W2012506704 hasConceptScore W2012506704C2779074116 @default.
- W2012506704 hasConceptScore W2012506704C2779801612 @default.
- W2012506704 hasConceptScore W2012506704C71240020 @default.
- W2012506704 hasConceptScore W2012506704C94412978 @default.
- W2012506704 hasIssue "1" @default.
- W2012506704 hasLocation W20125067041 @default.
- W2012506704 hasLocation W20125067042 @default.
- W2012506704 hasOpenAccess W2012506704 @default.
- W2012506704 hasPrimaryLocation W20125067041 @default.
- W2012506704 hasRelatedWork W1538408228 @default.
- W2012506704 hasRelatedWork W1978171807 @default.
- W2012506704 hasRelatedWork W2001258838 @default.
- W2012506704 hasRelatedWork W2003999125 @default.
- W2012506704 hasRelatedWork W2012506704 @default.
- W2012506704 hasRelatedWork W2015700143 @default.
- W2012506704 hasRelatedWork W2088480953 @default.
- W2012506704 hasRelatedWork W2324634728 @default.
- W2012506704 hasRelatedWork W2345954825 @default.
- W2012506704 hasRelatedWork W2808401557 @default.
- W2012506704 hasVolume "9" @default.
- W2012506704 isParatext "false" @default.
- W2012506704 isRetracted "false" @default.
- W2012506704 magId "2012506704" @default.
- W2012506704 workType "article" @default.