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• W2012508676 abstract "The objective of the first series of experiments was to assess whether melatonin treatment modifies the activity of the y-aminobutyric acid synthesizing enzyme, glutamic acid decarboxylase, in the preoptic-medial basal hypotnalamic area, cerebral cortex and cerebellar cortex of rats receiving 25 to 300 μg of melatonin in the early morning and late evening in the diurnal cycle. A significant increase of apparent Vmax and Km of the enzyme was found in the hypothalamus of rats killed at the 12th h of the light phase (i.e. the time when lights were turned off) and receiving 25 to 300 μg/kg of melatonin 3 h earlier. In the early morning, only a 300 μg/kg dose of melatonin (injected in the 1st h of the light phase) was effective to increase Vmax and Km of hypothalamic glutamic acid decarboxylase 3 h later. In cerebral and cerebellar cortices, increases in Vmax and Km of enzyme activity were apparent only in the evening and with the highest melatonin dose employed (300 μg/kg). In a second series of experiments the activity of melatonin to modify in vitro36CI influx by 900 x g pellets of rat preoptic-medial basal hypothalamic area was studied at the 4th and 12th h of the light phase of daily photoperiod. Melatonin increased 36CI− influx at a minimum concentration of 100 nM (in the morning) or 10 nM (in the evening). The effect of melatonin on 36CI− influx was prevented by co-incubation with 100 μM picrotoxin. Addition of 10 to 100 μM of y-aminobutyric acid to the resuspended 900 x g pellets brought about a dose-dependent increase of 36CI − influx. Preincubation with melatonin at threshold doses of 1 μM (in the morning) or 0.1 μM (in the evening) significantly augmented y-aminobutyric acid effect on 36CI− uptake. These results indicate that melatonin facilitates pre- and postsynaptic activities of y-aminobutyric acid neurons, particularly in the hypothalamus, through an effect that displays a diurnal sensitivity compatible with the documented activity of the hormone on a number of physiological functions." @default.
• W2012508676 created "2016-06-24" @default.
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• W2012508676 date "1989-12-01" @default.
• W2012508676 modified "2023-10-15" @default.
• W2012508676 title "Time-Dependent Effect of Melatonin on Glutamic Acid Decarboxylase Activity and³⁶CI^?Influx in Rat Hypothalamus" @default.
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• W2012508676 doi "https://doi.org/10.1111/j.1365-2826.1989.tb00145.x" @default.
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