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• W2012508812 abstract "The first part of the paper covers general aspects of virus safety. Current measures to avoid transmission of infections by transfusion are donor selection, including confidential unit exclusion, laboratory testing, and pathogen inactivation. Since testing and inactivation cannot guarantee the complete absence of pathogens for several reasons, appropriate selection of blood donors with as low as possible risk of transmissible infections still appears desirable. However, exclusion criteria are very unspecific with respect to the true donor infectivity, and the influence on the virus safety of blood products remains unknown. Furthermore, there are indications that many donors do not fully comply or actively bypass the selection procedure. It appears necessary to reevaluate current donor selection in order to reduce exclusion criteria to those which prove to be important and thus improve compliance of donors. A matter of debate is which tests have to be applied for testing of donors. Problems arise if a donor becomes test-positive just after the screening test was changed to a more sensitive procedure (the former test might have been false-negative). Open questions are: ‘How perfect needs to be confirmation of positive screening results for epidemiological evaluation?’ and ‘Is ALT testing still necessary?’. The pressure to introduce any test promising a marginal benefit at enormous costs could be reduced by a no-fault compensation scheme as introduced in Italy. The second part of the paper covers current problems with special viruses such as HBV (incidence, necessity of anti-HBc testing), HCV (residual risk, additional transmissions through anti-D immunoglobulin), new candidate viruses for non-A to -E hepatitis, the possible efficiency of HIV nucleic acid amplification testing, HTLV, and parvovirus B19 transmissions." @default.
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• W2012508812 date "2000-01-01" @default.
• W2012508812 modified "2023-09-27" @default.
• W2012508812 title "Virus Safety of Blood and Plasma Products in Germany – State of Knowledge and Open Problems" @default.
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• W2012508812 doi "https://doi.org/10.1159/000053541" @default.
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