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- W2012511306 abstract "The paper reviews some of the new approaches to the targeting of bioactive compounds. In particular, the results of artificially rendering macromolecules hydrophobic by nonpolar substituents are considered. This principle enabled us to develop a method for suppressing virus reproduction in cells with fatty acylated antiviral antibodies and also to enhance antisense activity of short complementary oligonucleotides. Some ideas for creation of drug-targeting systems based on self-assembling supramolecular complexes have been tested. In this respect, a possibility of using interpolyelectrolyte complexes of nucleic acids with polycations for targeting genetic material into cells is discussed. Within the limits of this concept, a new class of highly selective immunotoxins (‘respecrins’) representing supramolecular protein complexes in which toxin molecules are reversibly masked by antibodies to specific antigens of target cells has been developed." @default.
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- W2012511306 date "1994-01-01" @default.
- W2012511306 modified "2023-09-27" @default.
- W2012511306 title "New approaches to targeting bioactive compounds" @default.
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- W2012511306 doi "https://doi.org/10.1016/0168-3659(94)90150-3" @default.
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