Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012522788> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2012522788 abstract "To assess the long-term safety of the single-tablet combination of ibuprofen 800 mg and famotidine 26.6 mg.A phase 3b open-label study (NCT00984815) was conducted in 86 adults requiring daily non-steroidal anti-inflammatory drug (NSAID) administration for ≥12 months. The combination tablet of ibuprofen/famotidine was self-administered orally three times daily for up to 54 consecutive weeks. Adverse events (AEs) were collected beginning at the first dose and continued through completion (54 weeks). The Severity of Dyspepsia Assessment (SODA) questionnaire was completed by patients to assess tolerability.Most patients (65%) finished the trial, with 76% contributing data at 6 months, and 21% withdrew due to adverse effects. Overall and gastrointestinal AE discontinuation rates (21% and 13%, respectively) were lower than that previously reported with ibuprofen 2400 mg given alone. Each of the SODA subscale scores demonstrated improvement by week 6 and improved statistically significantly at week 24 and week 54. Of the cardiovascular AEs, hypertension was reported most frequently (9/86, 9.3%), with 3.5% determined to be drug related. Twelve serious AEs were reported by 9 of 86 (10%) patients; two were considered possibly related to the study medication (unstable angina and gastric ulcer). There were no reports of serious gastrointestinal or CV complications. Most AEs were mild or moderate in severity and not considered drug related.These data, together with previously reported findings of a significant decrease in upper gastrointestinal endoscopic ulcer rate at 6 months, support the overall safety, compliance, and tolerability of this single-tablet formulation." @default.
- W2012522788 created "2016-06-24" @default.
- W2012522788 creator A5004250800 @default.
- W2012522788 creator A5017975302 @default.
- W2012522788 creator A5032947707 @default.
- W2012522788 creator A5035404908 @default.
- W2012522788 creator A5056718731 @default.
- W2012522788 date "2015-01-09" @default.
- W2012522788 modified "2023-10-16" @default.
- W2012522788 title "One-year open-label safety evaluation of the fixed combination of ibuprofen and famotidine with a prospective analysis of dyspepsia" @default.
- W2012522788 cites W1599185368 @default.
- W2012522788 cites W1990824360 @default.
- W2012522788 cites W1998024620 @default.
- W2012522788 cites W2010818945 @default.
- W2012522788 cites W2040371948 @default.
- W2012522788 cites W2042863388 @default.
- W2012522788 cites W2050013926 @default.
- W2012522788 cites W2054812603 @default.
- W2012522788 cites W2055521278 @default.
- W2012522788 cites W2065321505 @default.
- W2012522788 cites W2072810447 @default.
- W2012522788 cites W2074464241 @default.
- W2012522788 cites W2080195990 @default.
- W2012522788 cites W2089180950 @default.
- W2012522788 cites W2094625675 @default.
- W2012522788 cites W2110575502 @default.
- W2012522788 cites W2133241284 @default.
- W2012522788 cites W2145158292 @default.
- W2012522788 cites W2152450482 @default.
- W2012522788 cites W2160947654 @default.
- W2012522788 cites W2166091732 @default.
- W2012522788 cites W2166146650 @default.
- W2012522788 cites W2170354330 @default.
- W2012522788 cites W2339197236 @default.
- W2012522788 cites W57554705 @default.
- W2012522788 doi "https://doi.org/10.1185/03007995.2014.999152" @default.
- W2012522788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25495134" @default.
- W2012522788 hasPublicationYear "2015" @default.
- W2012522788 type Work @default.
- W2012522788 sameAs 2012522788 @default.
- W2012522788 citedByCount "2" @default.
- W2012522788 countsByYear W20125227882016 @default.
- W2012522788 countsByYear W20125227882019 @default.
- W2012522788 crossrefType "journal-article" @default.
- W2012522788 hasAuthorship W2012522788A5004250800 @default.
- W2012522788 hasAuthorship W2012522788A5017975302 @default.
- W2012522788 hasAuthorship W2012522788A5032947707 @default.
- W2012522788 hasAuthorship W2012522788A5035404908 @default.
- W2012522788 hasAuthorship W2012522788A5056718731 @default.
- W2012522788 hasConcept C126322002 @default.
- W2012522788 hasConcept C197934379 @default.
- W2012522788 hasConcept C2778375690 @default.
- W2012522788 hasConcept C2778715236 @default.
- W2012522788 hasConcept C2779944601 @default.
- W2012522788 hasConcept C2781263782 @default.
- W2012522788 hasConcept C71924100 @default.
- W2012522788 hasConcept C90924648 @default.
- W2012522788 hasConcept C98274493 @default.
- W2012522788 hasConceptScore W2012522788C126322002 @default.
- W2012522788 hasConceptScore W2012522788C197934379 @default.
- W2012522788 hasConceptScore W2012522788C2778375690 @default.
- W2012522788 hasConceptScore W2012522788C2778715236 @default.
- W2012522788 hasConceptScore W2012522788C2779944601 @default.
- W2012522788 hasConceptScore W2012522788C2781263782 @default.
- W2012522788 hasConceptScore W2012522788C71924100 @default.
- W2012522788 hasConceptScore W2012522788C90924648 @default.
- W2012522788 hasConceptScore W2012522788C98274493 @default.
- W2012522788 hasLocation W20125227881 @default.
- W2012522788 hasLocation W20125227882 @default.
- W2012522788 hasOpenAccess W2012522788 @default.
- W2012522788 hasPrimaryLocation W20125227881 @default.
- W2012522788 hasRelatedWork W1490515507 @default.
- W2012522788 hasRelatedWork W2012522788 @default.
- W2012522788 hasRelatedWork W2057339290 @default.
- W2012522788 hasRelatedWork W2059313976 @default.
- W2012522788 hasRelatedWork W2089245388 @default.
- W2012522788 hasRelatedWork W2113068515 @default.
- W2012522788 hasRelatedWork W2792428998 @default.
- W2012522788 hasRelatedWork W2896659597 @default.
- W2012522788 hasRelatedWork W3115293888 @default.
- W2012522788 hasRelatedWork W2741614006 @default.
- W2012522788 isParatext "false" @default.
- W2012522788 isRetracted "false" @default.
- W2012522788 magId "2012522788" @default.
- W2012522788 workType "article" @default.