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• W2012523768 abstract "Lipophilic chalcones and their conformationally restricted analogues were synthesized and evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv strain. Compounds 16, 24, 25a and 25c were found to be active MIC at 60, 30, 3.5 and 7.5 μg-mL(-1). In vitro cytotoxicity of compounds 16, 24, 25a, 25c and 26 in non-cancerous human epithelial kidney cell line (HEK-293) showed that most active compound 25a was approximately 2.85 times selective towards tubercular versus healthy cells whereas compound 24 was found to be 16 times selective." @default.
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• W2012523768 date "2013-03-01" @default.
• W2012523768 modified "2023-09-30" @default.
• W2012523768 title "Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents" @default.
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• W2012523768 doi "https://doi.org/10.1016/j.bmcl.2012.12.096" @default.
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