FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012533893> ?p ?o ?g. }

• W2012533893 abstract "The contractibility of blood vessels depends on their normal structure and the availability of calcium ions; it changes under the influence of numerous contracting and relaxing factors, which control the activities of various pathways of intracellular and intercellular signaling. The main aim of the study was to investigate, by means of perfusion pressure in rat tail arteries, the role of Ca2+ in vascular response to α-1 adrenoceptor activation by phenylephrine (PHE) and Bay K8644 agonist of the L-type calcium channel and caffeine before and after a post-mortem interval (PMI) of 2, 4, 6 and 8 h. A phasic increase of perfusion pressure in rat tail arteries, as induced by PHE or caffeine, in Ca2+-free solutions was used as an indicator of intracellular Ca2+ release through the inositol 1,4,5-triphosphate and ryanodine receptor pathways, respectively. In Ca2+-free-ethylene glycol tetraacetic acid (EGTA)-poly(sodium styrenesulfonate) (PSS) and in Ca2+-EGTA-PSS, the PHE induced elevation of perfusion pressure significantly decreased. Vascular responses to caffeine (20 mmol/1) in Ca2+-free-EGTA-PSS, with an increase of PMI from 2-8 h, did not change significantly. A similar effect was observed with vascular responses to KCl 40 mmol/1 in Ca2+-EGTA-PSS. To confirm whether the inhibitory effect of 2, 4, 6 and 8 h PMI was mediated through the formation of NO, nitro-L-arginine (L-NNA), a potent NO synthase inhibitor, was used. Exposure to L-NNA (10-5 M) blocked the inhibition induced by an increase of PMI. The blocked effects of L-NNA were reversed by L-arginine (10-4 M). In conclusion, these patterns of change in artery responses provide insight into the post-mortem change in the receptor-mediated signaling components in epithelial and smooth muscle cells, and support the further study of post-mortem vascular responses triggered by G protein-coupled receptors (metabotropic) and channel-linked receptors (ionotropic) as potential markers for estimating short and long-term PMIs, respectively." @default.
• W2012533893 created "2016-06-24" @default.
• W2012533893 creator A5024271749 @default.
• W2012533893 creator A5029473517 @default.
• W2012533893 creator A5090031419 @default.
• W2012533893 date "2014-12-03" @default.
• W2012533893 modified "2023-09-23" @default.
• W2012533893 title "Comparison of the post-mortem interval on the effect of vascular responses to the activation of ionotropic and metabotropic receptors" @default.
• W2012533893 cites W1534709134 @default.
• W2012533893 cites W1966322594 @default.
• W2012533893 cites W1967311126 @default.
• W2012533893 cites W1977394169 @default.
• W2012533893 cites W1983665859 @default.
• W2012533893 cites W1995989576 @default.
• W2012533893 cites W2016575029 @default.
• W2012533893 cites W2023158378 @default.
• W2012533893 cites W2023184179 @default.
• W2012533893 cites W2031073874 @default.
• W2012533893 cites W2033013903 @default.
• W2012533893 cites W2038733394 @default.
• W2012533893 cites W2038763722 @default.
• W2012533893 cites W2044483451 @default.
• W2012533893 cites W2079474210 @default.
• W2012533893 cites W2083418299 @default.
• W2012533893 cites W2085273994 @default.
• W2012533893 cites W2115202433 @default.
• W2012533893 cites W2124343254 @default.
• W2012533893 cites W2126624423 @default.
• W2012533893 cites W2395600245 @default.
• W2012533893 cites W2413552882 @default.
• W2012533893 doi "https://doi.org/10.3892/br.2014.396" @default.
• W2012533893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4360861" @default.
• W2012533893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25798248" @default.
• W2012533893 hasPublicationYear "2014" @default.
• W2012533893 type Work @default.
• W2012533893 sameAs 2012533893 @default.
• W2012533893 citedByCount "1" @default.
• W2012533893 countsByYear W20125338932021 @default.
• W2012533893 crossrefType "journal-article" @default.
• W2012533893 hasAuthorship W2012533893A5024271749 @default.
• W2012533893 hasAuthorship W2012533893A5029473517 @default.
• W2012533893 hasAuthorship W2012533893A5090031419 @default.
• W2012533893 hasBestOaLocation W20125338931 @default.
• W2012533893 hasConcept C113217602 @default.
• W2012533893 hasConcept C115955781 @default.
• W2012533893 hasConcept C126322002 @default.
• W2012533893 hasConcept C134018914 @default.
• W2012533893 hasConcept C170493617 @default.
• W2012533893 hasConcept C181080969 @default.
• W2012533893 hasConcept C185592680 @default.
• W2012533893 hasConcept C2777658833 @default.
• W2012533893 hasConcept C2777952589 @default.
• W2012533893 hasConcept C2778500429 @default.
• W2012533893 hasConcept C2779395532 @default.
• W2012533893 hasConcept C2992686903 @default.
• W2012533893 hasConcept C519063684 @default.
• W2012533893 hasConcept C55493867 @default.
• W2012533893 hasConcept C61174792 @default.
• W2012533893 hasConcept C71924100 @default.
• W2012533893 hasConcept C84393581 @default.
• W2012533893 hasConcept C86803240 @default.
• W2012533893 hasConceptScore W2012533893C113217602 @default.
• W2012533893 hasConceptScore W2012533893C115955781 @default.
• W2012533893 hasConceptScore W2012533893C126322002 @default.
• W2012533893 hasConceptScore W2012533893C134018914 @default.
• W2012533893 hasConceptScore W2012533893C170493617 @default.
• W2012533893 hasConceptScore W2012533893C181080969 @default.
• W2012533893 hasConceptScore W2012533893C185592680 @default.
• W2012533893 hasConceptScore W2012533893C2777658833 @default.
• W2012533893 hasConceptScore W2012533893C2777952589 @default.
• W2012533893 hasConceptScore W2012533893C2778500429 @default.
• W2012533893 hasConceptScore W2012533893C2779395532 @default.
• W2012533893 hasConceptScore W2012533893C2992686903 @default.
• W2012533893 hasConceptScore W2012533893C519063684 @default.
• W2012533893 hasConceptScore W2012533893C55493867 @default.
• W2012533893 hasConceptScore W2012533893C61174792 @default.
• W2012533893 hasConceptScore W2012533893C71924100 @default.
• W2012533893 hasConceptScore W2012533893C84393581 @default.
• W2012533893 hasConceptScore W2012533893C86803240 @default.
• W2012533893 hasLocation W20125338931 @default.
• W2012533893 hasLocation W20125338932 @default.
• W2012533893 hasLocation W20125338933 @default.
• W2012533893 hasLocation W20125338934 @default.
• W2012533893 hasOpenAccess W2012533893 @default.
• W2012533893 hasPrimaryLocation W20125338931 @default.
• W2012533893 hasRelatedWork W1971900652 @default.
• W2012533893 hasRelatedWork W1996586953 @default.
• W2012533893 hasRelatedWork W1998592605 @default.
• W2012533893 hasRelatedWork W2011224208 @default.
• W2012533893 hasRelatedWork W2012533893 @default.
• W2012533893 hasRelatedWork W2016428260 @default.
• W2012533893 hasRelatedWork W2091422939 @default.
• W2012533893 hasRelatedWork W2413553882 @default.
• W2012533893 hasRelatedWork W3151667968 @default.
• W2012533893 hasRelatedWork W2409072238 @default.
• W2012533893 isParatext "false" @default.
• W2012533893 isRetracted "false" @default.
• W2012533893 magId "2012533893" @default.
• W2012533893 workType "article" @default.