FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012536005> ?p ?o ?g. }

• W2012536005 endingPage "218" @default.
• W2012536005 startingPage "213" @default.
• W2012536005 abstract "Therapeutic trials of 1alpha,25(OH)(2)D(3) and related synthetic analogs are merited in diverse clinical fields, including treatment or prevention of bone disease, cancer, immune-mediated diseases, cardiovascular diseases, and prostatic hypertrophy. Potential difficulties of carrying out such trials successfully, include experimental data suggesting relatively modest therapeutic effects of 1alpha,25(OH)(2)D(3) analogs as stand-alone intervention and the likely requirement for large study group size and lengthy follow-up periods, if individual prophylactic effects are to be proven. Thus, it may be wise to identify patient groups with multiple potential benefits, accelerated disease risks, and the possibility for exploring synergistic pharmacological effects, in whom to carry out clinical trials of 1alpha,25(OH)(2)D(3) analogs. With this consideration in mind, the suitability of kidney transplant recipients for such studies is discussed. Although, highly effective in reversing end-stage renal disease, kidney transplantation continues to be limited by heightened risk of osteoporosis, persistent hyperparathyroidism, acute and chronic immunological injury, new cancer diagnosis, and cardiovascular events. In addition, kidney transplant recipients generally receive multiple immunosuppressants with a high prevalence of medication-related toxicities. Finally, it is pointed out that clinical trials carried out in organ transplant recipients provide a unique opportunity for longitudinal comparison of target tissue structural and gene expression profiles among treated and control patient groups. It is proposed that addition of a 1alpha,25(OH)(2)D(3) analog to conventional post-kidney transplant medication regimens is likely to be associated with measurable effects to prevent or retard multiple important complications and that this patient group is especially suitable for carrying out clinical trials of these compounds." @default.
• W2012536005 created "2016-06-24" @default.
• W2012536005 creator A5030580193 @default.
• W2012536005 creator A5086083991 @default.
• W2012536005 date "2005-10-01" @default.
• W2012536005 modified "2023-09-26" @default.
• W2012536005 title "Multiple potential clinical benefits for 1α,25-dihydroxyvitamin D3 analogs in kidney transplant recipients" @default.
• W2012536005 cites W1488524199 @default.
• W2012536005 cites W1833265069 @default.
• W2012536005 cites W1925602349 @default.
• W2012536005 cites W1973511139 @default.
• W2012536005 cites W1979323159 @default.
• W2012536005 cites W1980817286 @default.
• W2012536005 cites W1982078389 @default.
• W2012536005 cites W2000145095 @default.
• W2012536005 cites W2003875170 @default.
• W2012536005 cites W2009889462 @default.
• W2012536005 cites W2015858614 @default.
• W2012536005 cites W2023321844 @default.
• W2012536005 cites W2025025945 @default.
• W2012536005 cites W2026399893 @default.
• W2012536005 cites W2030555226 @default.
• W2012536005 cites W2051674059 @default.
• W2012536005 cites W2060597065 @default.
• W2012536005 cites W2064775052 @default.
• W2012536005 cites W2065114142 @default.
• W2012536005 cites W2065195395 @default.
• W2012536005 cites W2068547359 @default.
• W2012536005 cites W2068806064 @default.
• W2012536005 cites W2085336491 @default.
• W2012536005 cites W2089739646 @default.
• W2012536005 cites W2089883050 @default.
• W2012536005 cites W2095483193 @default.
• W2012536005 cites W2098974363 @default.
• W2012536005 cites W2102185935 @default.
• W2012536005 cites W2105417592 @default.
• W2012536005 cites W2109082501 @default.
• W2012536005 cites W2110924616 @default.
• W2012536005 cites W2114358746 @default.
• W2012536005 cites W2114844476 @default.
• W2012536005 cites W2114849059 @default.
• W2012536005 cites W2122372926 @default.
• W2012536005 cites W2128488710 @default.
• W2012536005 cites W2133666217 @default.
• W2012536005 cites W2141976681 @default.
• W2012536005 cites W2158320781 @default.
• W2012536005 cites W2165084323 @default.
• W2012536005 cites W2167960918 @default.
• W2012536005 cites W2171234521 @default.
• W2012536005 cites W2333378480 @default.
• W2012536005 cites W4233469193 @default.
• W2012536005 cites W4246027456 @default.
• W2012536005 cites W4251211214 @default.
• W2012536005 cites W1987343217 @default.
• W2012536005 doi "https://doi.org/10.1016/j.jsbmb.2005.06.014" @default.
• W2012536005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16026980" @default.
• W2012536005 hasPublicationYear "2005" @default.
• W2012536005 type Work @default.
• W2012536005 sameAs 2012536005 @default.
• W2012536005 citedByCount "9" @default.
• W2012536005 countsByYear W20125360052012 @default.
• W2012536005 countsByYear W20125360052016 @default.
• W2012536005 countsByYear W20125360052017 @default.
• W2012536005 crossrefType "journal-article" @default.
• W2012536005 hasAuthorship W2012536005A5030580193 @default.
• W2012536005 hasAuthorship W2012536005A5086083991 @default.
• W2012536005 hasConcept C121608353 @default.
• W2012536005 hasConcept C126322002 @default.
• W2012536005 hasConcept C177713679 @default.
• W2012536005 hasConcept C2778653478 @default.
• W2012536005 hasConcept C2779134260 @default.
• W2012536005 hasConcept C2780091579 @default.
• W2012536005 hasConcept C2780303639 @default.
• W2012536005 hasConcept C2911091166 @default.
• W2012536005 hasConcept C535046627 @default.
• W2012536005 hasConcept C71924100 @default.
• W2012536005 hasConceptScore W2012536005C121608353 @default.
• W2012536005 hasConceptScore W2012536005C126322002 @default.
• W2012536005 hasConceptScore W2012536005C177713679 @default.
• W2012536005 hasConceptScore W2012536005C2778653478 @default.
• W2012536005 hasConceptScore W2012536005C2779134260 @default.
• W2012536005 hasConceptScore W2012536005C2780091579 @default.
• W2012536005 hasConceptScore W2012536005C2780303639 @default.
• W2012536005 hasConceptScore W2012536005C2911091166 @default.
• W2012536005 hasConceptScore W2012536005C535046627 @default.
• W2012536005 hasConceptScore W2012536005C71924100 @default.
• W2012536005 hasIssue "1-2" @default.
• W2012536005 hasLocation W20125360051 @default.
• W2012536005 hasLocation W20125360052 @default.
• W2012536005 hasOpenAccess W2012536005 @default.
• W2012536005 hasPrimaryLocation W20125360051 @default.
• W2012536005 hasRelatedWork W1540807578 @default.
• W2012536005 hasRelatedWork W1718748228 @default.
• W2012536005 hasRelatedWork W1990329229 @default.
• W2012536005 hasRelatedWork W2016976166 @default.
• W2012536005 hasRelatedWork W2083876283 @default.
• W2012536005 hasRelatedWork W2378019284 @default.
• W2012536005 hasRelatedWork W2382568077 @default.

• next