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- W2012536183 endingPage "802" @default.
- W2012536183 startingPage "783" @default.
- W2012536183 abstract "Several pieces of legislation have led to an increased interest in the use of in silico methods, specifically the formation of chemical categories for the assessment of toxicological endpoints. For a number of endpoints, this requires a detailed knowledge of the electrophilic reaction chemistry that governs the ability of an exogenous chemical to form a covalent adduct. Historically, this chemistry has been defined as compilations of structural alerts without documenting the associated electrophilic chemistry mechanisms. To address this, this article has reviewed the literature defining the structural alerts associated with covalent protein binding and detailed the associated electrophilic reaction chemistry. This information is useful to both toxicologists and regulators when using the chemical category approach to fill data gaps for endpoints involving covalent protein binding. The structural alerts and associated electrophilic reaction chemistry outlined in this review have been incorporated into the OECD (Q)SAR Toolbox, a freely available software tool designed to fill data gaps in a regulatory environment without the need for further animal testing." @default.
- W2012536183 created "2016-06-24" @default.
- W2012536183 creator A5035063457 @default.
- W2012536183 creator A5042404534 @default.
- W2012536183 creator A5054905346 @default.
- W2012536183 creator A5084970371 @default.
- W2012536183 date "2011-08-02" @default.
- W2012536183 modified "2023-09-24" @default.
- W2012536183 title "A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity" @default.
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