FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012538511> ?p ?o ?g. }

• W2012538511 endingPage "352" @default.
• W2012538511 startingPage "336" @default.
• W2012538511 abstract "Glycine receptors (GlyRs), aside from GABA(A) receptors, mediate fast postsynaptic inhibition in the mammalian nervous system. Spatial and temporal expression of the genes encoding ligand-binding alpha subunits (alpha1-alpha4) and the structural beta subunit leads to the formation of various GlyR isoforms. Currently, the idea of the GlyRs containing the adult alpha1 subunit replacing those with the neonatal alpha2 subunit during early postnatal development predominates. Here, we describe the patterns of expression of the GlyR alpha1 and alpha2 subunit genes in the rat auditory brainstem between postnatal day (P) 0 and P20, by using both nonradioactive and radioactive in situ hybridization. We show that the alpha1 subunit mRNA appears throughout the auditory brainstem during the first 8 postnatal days, which resembles the time of onset described within the spinal cord. In the rostral auditory nuclei (nuclei of the lateral lemniscus and inferior colliculus), the alpha1 subunit transcript appears later (P8) than in the caudal nuclei (cochlear nuclear complex and superior olivary complex; P0). Surprisingly, we found that low levels of the alpha2 subunit transcript are present in the auditory brainstem at birth and persist throughout the period analyzed. However, alpha2 subunit mRNA is present at high levels in other neonatal brainstem structures, such as cranial motor nuclei. Therefore, we conclude that the changes in GlyR composition in the auditory brainstem deviate from the classic alpha2 to alpha1 subunit switch observed in spinal cord. Our data suggest that genes for other GlyR subunits (e.g., alpha3 and alpha4) may be expressed during early development in the auditory brainstem." @default.
• W2012538511 created "2016-06-24" @default.
• W2012538511 creator A5003004141 @default.
• W2012538511 creator A5009192388 @default.
• W2012538511 creator A5060958651 @default.
• W2012538511 creator A5079490188 @default.
• W2012538511 date "2001-01-01" @default.
• W2012538511 modified "2023-10-16" @default.
• W2012538511 title "Localization of rat glycine receptor ?1 and ?2 subunit transcripts in the developing auditory brainstem" @default.
• W2012538511 cites W1488934481 @default.
• W2012538511 cites W1509513803 @default.
• W2012538511 cites W1519429960 @default.
• W2012538511 cites W1554378628 @default.
• W2012538511 cites W1599587228 @default.
• W2012538511 cites W1760781143 @default.
• W2012538511 cites W1836652085 @default.
• W2012538511 cites W1870793636 @default.
• W2012538511 cites W1872543256 @default.
• W2012538511 cites W1905325352 @default.
• W2012538511 cites W1957270349 @default.
• W2012538511 cites W1966951089 @default.
• W2012538511 cites W1968031887 @default.
• W2012538511 cites W1973795772 @default.
• W2012538511 cites W1978884918 @default.
• W2012538511 cites W1982135535 @default.
• W2012538511 cites W1982327152 @default.
• W2012538511 cites W1983500946 @default.
• W2012538511 cites W1983799682 @default.
• W2012538511 cites W1986210298 @default.
• W2012538511 cites W1990166061 @default.
• W2012538511 cites W1991818630 @default.
• W2012538511 cites W1995268545 @default.
• W2012538511 cites W1996788978 @default.
• W2012538511 cites W1997781977 @default.
• W2012538511 cites W2003912094 @default.
• W2012538511 cites W2012249011 @default.
• W2012538511 cites W2013161023 @default.
• W2012538511 cites W2015417958 @default.
• W2012538511 cites W2016586373 @default.
• W2012538511 cites W2021086824 @default.
• W2012538511 cites W2039629308 @default.
• W2012538511 cites W2042393717 @default.
• W2012538511 cites W2044912570 @default.
• W2012538511 cites W2046390092 @default.
• W2012538511 cites W2049879893 @default.
• W2012538511 cites W2063744756 @default.
• W2012538511 cites W2064280850 @default.
• W2012538511 cites W2064946820 @default.
• W2012538511 cites W2068118330 @default.
• W2012538511 cites W2073031109 @default.
• W2012538511 cites W2076171494 @default.
• W2012538511 cites W2078702193 @default.
• W2012538511 cites W2088638836 @default.
• W2012538511 cites W2089978225 @default.
• W2012538511 cites W2093413520 @default.
• W2012538511 cites W2115212745 @default.
• W2012538511 cites W2158224529 @default.
• W2012538511 cites W4251931813 @default.
• W2012538511 doi "https://doi.org/10.1002/cne.1319" @default.
• W2012538511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11550176" @default.
• W2012538511 hasPublicationYear "2001" @default.
• W2012538511 type Work @default.
• W2012538511 sameAs 2012538511 @default.
• W2012538511 citedByCount "65" @default.
• W2012538511 countsByYear W20125385112012 @default.
• W2012538511 countsByYear W20125385112013 @default.
• W2012538511 countsByYear W20125385112014 @default.
• W2012538511 countsByYear W20125385112015 @default.
• W2012538511 countsByYear W20125385112016 @default.
• W2012538511 countsByYear W20125385112017 @default.
• W2012538511 countsByYear W20125385112018 @default.
• W2012538511 countsByYear W20125385112019 @default.
• W2012538511 countsByYear W20125385112020 @default.
• W2012538511 countsByYear W20125385112021 @default.
• W2012538511 crossrefType "journal-article" @default.
• W2012538511 hasAuthorship W2012538511A5003004141 @default.
• W2012538511 hasAuthorship W2012538511A5009192388 @default.
• W2012538511 hasAuthorship W2012538511A5060958651 @default.
• W2012538511 hasAuthorship W2012538511A5079490188 @default.
• W2012538511 hasConcept C104292427 @default.
• W2012538511 hasConcept C104317684 @default.
• W2012538511 hasConcept C105580179 @default.
• W2012538511 hasConcept C169760540 @default.
• W2012538511 hasConcept C170493617 @default.
• W2012538511 hasConcept C197341189 @default.
• W2012538511 hasConcept C2775980177 @default.
• W2012538511 hasConcept C2776178378 @default.
• W2012538511 hasConcept C2777662796 @default.
• W2012538511 hasConcept C2777756961 @default.
• W2012538511 hasConcept C2777969728 @default.
• W2012538511 hasConcept C2778037994 @default.
• W2012538511 hasConcept C2778304665 @default.
• W2012538511 hasConcept C2780723820 @default.
• W2012538511 hasConcept C2780775167 @default.
• W2012538511 hasConcept C35599011 @default.
• W2012538511 hasConcept C515207424 @default.
• W2012538511 hasConcept C54355233 @default.
• W2012538511 hasConcept C551621295 @default.

• next