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• W2012550835 abstract "The circulating concentration of placental protein 12 was measured by radioimmunoassay in 109 pregnant women. The effect on the serum PP12 level of temperature, repeat freezing and thawing, and day-to-day and diurnal variation were assessed and the post partum changes of levels were studied. On average, PP12 levels in plasma are about one-half of those in serum in the same individual. PP12 immunoreactivity is destroyed by heating but not by repeated freezing and thawing. Changes in serum PP12 levels at various times of day showed a significant and consistent diurnal variation (F=7.21; d.f. 24; 96; P<0.001). The peak mean (±s.e.m.) value at 0800 h (80.8±8.7 ng/ml) was 41 per cent higher than the 24-h mean (P<0.05), and the nadir concentration at 1400 h (40.4±5.4 ng/ml) was 29 per cent lower than the 24-h mean (P<0.025). There is also considerable day-to-day variation (up to 72 per cent) in serum PP12 levels. If serum samples are taken at 0700 h, there is a slight negative correlation between PP12 concentration and placental weight (P<0.05), but not between PP12 level and birthweight of the child. In term pregnancy, the levels taken at 0700 h are higher (163.7±12.4 ng/ml) than at 0900 to 1300 h (115.7±11.4 ng/ml, P<0.001). The PP12 level is not affected by labour. Post partum, the levels rise during the first hour and then decline between one and three hours at a rate corresponding to a half-life of 4 h 40 min (median). The non-pregnant PP12 level is sometimes reached by as early as three hours after delivery, but in many cases there is a secondary rise thereafter. This rise is not correlated to suckling. Our results show that the type of blood sampling as well as its exact timing are critical determinants in the clinical evaluation of maternal serum PP12 levels. The pattern of diurnal variation of serum PP12 level resembles that of plasma prolactin and cortisol, and indicates a possible relationship to hormonal influence." @default.
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• W2012550835 date "1984-05-01" @default.
• W2012550835 modified "2023-10-16" @default.
• W2012550835 title "Placental protein 12 (PP12): Factors affecting levels in late pregnancy" @default.
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• W2012550835 doi "https://doi.org/10.1016/s0143-4004(84)80034-x" @default.
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