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- W2012551500 abstract "Male Fischer 344 rats and male B6C3F1 mice (10/species/group) were exposed to ethylene 6 h/day, 5 days/week, for 4 weeks. The ethylene target concentrations were 0, 40, 1000, and 3000 ppm. An ethylene oxide (EO) control group for each species was exposed under the same conditions at a target concentration of 200 ppm. Bone marrow was collected approximately 24 h after the final exposure. Polychromatic erythrocyte (PCE) to normochromatic erythrocyte (NCE) ratios were determined and 2000 PCE/animal were scored for the presence of micronuclei. Ethylene did not produce statistically significant, exposure-related increases in the frequency of micronucleated PCE (MNPCE) in the bone marrow of either rats or mice when compared to air-exposed control animals. As expected, EO exposure resulted in significant increases in the frequencies of MNPCE in both species." @default.
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- W2012551500 date "1994-07-01" @default.
- W2012551500 modified "2023-10-09" @default.
- W2012551500 title "Effects of ethylene on micronucleus formation in the bone marrow of rats and mice following four weeks of inhalation exposure" @default.
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- W2012551500 doi "https://doi.org/10.1016/0165-7992(94)90051-5" @default.
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