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- W2012551676 abstract "Abstract We found that the anti-cancer drugs of mitomycin C and etoposide will induce chromatin decondensation in human PLC/PRF/5 hepatoma cells, while the tumor promoter thapsigargin instead induces chromatin condensation. Both of these changes are subsequently followed by internucleosomal DNA cleavage and cell death characteristic to apoptosis. The p53 protein, which is known to induce apoptosis, increased in the anti-cancer drug-treated cells but not in thapsigargin-treated cells, thereby strongly suggesting that p53-dependent and -independent pathways linked to apoptosis exist in this hepatoma cell line." @default.
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- W2012551676 modified "2023-09-30" @default.
- W2012551676 title "Apoptosis and p53 protein expression in human hepatoma cells induced by etoposide, mitomycin C and thapsigargin" @default.
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