Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012553513> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2012553513 endingPage "58" @default.
- W2012553513 startingPage "52" @default.
- W2012553513 abstract "Although lobeline and nicotine are both potent ligands at neuronal nicotinic cholinergic receptors, chronic lobeline does not produce the upregulation of nicotinic receptors found with chronic nicotine or the less potent agonist anabasine. Since agonist-induced receptor upregulation is believed to result from receptor desensitization during chronic treatment, this suggests that lobeline may not desensitize neuronal nicotinic receptors. We addressed this question by comparing lobeline- and nicotine-induced desensitization of the actions of nicotine, using body temperature and locomotor activity as dependent variables. Nicotine pretreatment reduced the hypothermia and locomotor suppression produced by a subsequent nicotine challenge, whereas lobeline pretreatment did not. When tested alone, both nicotine and lobeline reduced locomotor activity and body temperature to a similar degree, but lobeline was significantly less potent. The reductions in activity and temperature produced by nicotine were significantly attenuated in chlorisondamine-treated mice, whereas treatment with this long-lasting nicotinic cholinergic antagonist did not alter the effects of lobeline. Thus, nicotine and lobeline appear to differ in their ability to produce desensitization. Furthermore, the effects of these two compounds on locomotor activity and body temperature may be mediated via different mechanisma. © 1994 Wiley-Liss, Inc." @default.
- W2012553513 created "2016-06-24" @default.
- W2012553513 creator A5012588252 @default.
- W2012553513 creator A5053457722 @default.
- W2012553513 creator A5089660173 @default.
- W2012553513 date "1994-01-01" @default.
- W2012553513 modified "2023-09-24" @default.
- W2012553513 title "Differential effects of pretreatment with nicotine and lobeline on nicotine-induced changes in body temperature and locomotor activity in mice" @default.
- W2012553513 cites W1968485866 @default.
- W2012553513 cites W1971869239 @default.
- W2012553513 cites W1977049293 @default.
- W2012553513 cites W1981958007 @default.
- W2012553513 cites W1992826305 @default.
- W2012553513 cites W1993410602 @default.
- W2012553513 cites W2003598035 @default.
- W2012553513 cites W2005274709 @default.
- W2012553513 cites W2012856716 @default.
- W2012553513 cites W2015839973 @default.
- W2012553513 cites W2020245201 @default.
- W2012553513 cites W2023652517 @default.
- W2012553513 cites W2024599954 @default.
- W2012553513 cites W2041656699 @default.
- W2012553513 cites W2057369989 @default.
- W2012553513 cites W2057983183 @default.
- W2012553513 cites W2080919332 @default.
- W2012553513 cites W2092446825 @default.
- W2012553513 cites W2102510891 @default.
- W2012553513 cites W850394169 @default.
- W2012553513 doi "https://doi.org/10.1002/ddr.430310109" @default.
- W2012553513 hasPublicationYear "1994" @default.
- W2012553513 type Work @default.
- W2012553513 sameAs 2012553513 @default.
- W2012553513 citedByCount "24" @default.
- W2012553513 countsByYear W20125535132013 @default.
- W2012553513 crossrefType "journal-article" @default.
- W2012553513 hasAuthorship W2012553513A5012588252 @default.
- W2012553513 hasAuthorship W2012553513A5053457722 @default.
- W2012553513 hasAuthorship W2012553513A5089660173 @default.
- W2012553513 hasConcept C126322002 @default.
- W2012553513 hasConcept C134018914 @default.
- W2012553513 hasConcept C170493617 @default.
- W2012553513 hasConcept C185592680 @default.
- W2012553513 hasConcept C188987157 @default.
- W2012553513 hasConcept C22885893 @default.
- W2012553513 hasConcept C2776880047 @default.
- W2012553513 hasConcept C2776975794 @default.
- W2012553513 hasConcept C2777012931 @default.
- W2012553513 hasConcept C2777301948 @default.
- W2012553513 hasConcept C2778938600 @default.
- W2012553513 hasConcept C2779547902 @default.
- W2012553513 hasConcept C2779570518 @default.
- W2012553513 hasConcept C2779779143 @default.
- W2012553513 hasConcept C2780374058 @default.
- W2012553513 hasConcept C55493867 @default.
- W2012553513 hasConcept C71924100 @default.
- W2012553513 hasConcept C80161118 @default.
- W2012553513 hasConcept C84393581 @default.
- W2012553513 hasConcept C98274493 @default.
- W2012553513 hasConceptScore W2012553513C126322002 @default.
- W2012553513 hasConceptScore W2012553513C134018914 @default.
- W2012553513 hasConceptScore W2012553513C170493617 @default.
- W2012553513 hasConceptScore W2012553513C185592680 @default.
- W2012553513 hasConceptScore W2012553513C188987157 @default.
- W2012553513 hasConceptScore W2012553513C22885893 @default.
- W2012553513 hasConceptScore W2012553513C2776880047 @default.
- W2012553513 hasConceptScore W2012553513C2776975794 @default.
- W2012553513 hasConceptScore W2012553513C2777012931 @default.
- W2012553513 hasConceptScore W2012553513C2777301948 @default.
- W2012553513 hasConceptScore W2012553513C2778938600 @default.
- W2012553513 hasConceptScore W2012553513C2779547902 @default.
- W2012553513 hasConceptScore W2012553513C2779570518 @default.
- W2012553513 hasConceptScore W2012553513C2779779143 @default.
- W2012553513 hasConceptScore W2012553513C2780374058 @default.
- W2012553513 hasConceptScore W2012553513C55493867 @default.
- W2012553513 hasConceptScore W2012553513C71924100 @default.
- W2012553513 hasConceptScore W2012553513C80161118 @default.
- W2012553513 hasConceptScore W2012553513C84393581 @default.
- W2012553513 hasConceptScore W2012553513C98274493 @default.
- W2012553513 hasIssue "1" @default.
- W2012553513 hasLocation W20125535131 @default.
- W2012553513 hasOpenAccess W2012553513 @default.
- W2012553513 hasPrimaryLocation W20125535131 @default.
- W2012553513 hasRelatedWork W1965391128 @default.
- W2012553513 hasRelatedWork W1981283169 @default.
- W2012553513 hasRelatedWork W1984455338 @default.
- W2012553513 hasRelatedWork W2012553513 @default.
- W2012553513 hasRelatedWork W2032761686 @default.
- W2012553513 hasRelatedWork W2036834560 @default.
- W2012553513 hasRelatedWork W2165094621 @default.
- W2012553513 hasRelatedWork W2899831411 @default.
- W2012553513 hasRelatedWork W2187157082 @default.
- W2012553513 hasRelatedWork W2318484436 @default.
- W2012553513 hasVolume "31" @default.
- W2012553513 isParatext "false" @default.
- W2012553513 isRetracted "false" @default.
- W2012553513 magId "2012553513" @default.
- W2012553513 workType "article" @default.