Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012572826> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2012572826 endingPage "1017" @default.
- W2012572826 startingPage "1015" @default.
- W2012572826 abstract "Intense interest has been generated by the discovery that reactive oxygen species can function as intracellular second messengers. Reactive oxygen species have been implicated in diverse cellular processes, including growth factor signal transduction, gene expression and apoptosis. Additionally, there is evidence for proteins that are regulated by redox environment through the reversible oxidation of their cysteine residues. However, the direct reaction of reactive oxygen species with cysteine at physiological concentrations is generally a slow process, suggesting that intermediates are required to convey efficiently the oxidative stimulus. Here, we discuss the evidence that DSOs (disulphide-S-oxides) are formed from glutathione under oxidizing conditions and specifically modulate the redox status of thiols, indicating the existence of specialized cellular oxidative pathways. DSO inactivated glyceraldehyde 3-phosphate and alcohol dehydrogenases and released zinc from metallothionein and a zinc finger domain. In contrast, equivalent concentrations of H(2)O(2) showed minimal effect. The antioxidants ascorbate, NADH, trolox and melatonin were unable to quench DSO-induced oxidation. These findings support the paradigm of oxidative signal transduction and provide a general pathway whereby reactive oxygen species can convert thiols into disulphides." @default.
- W2012572826 created "2016-06-24" @default.
- W2012572826 creator A5038425390 @default.
- W2012572826 creator A5044707123 @default.
- W2012572826 creator A5079348097 @default.
- W2012572826 date "2004-10-26" @default.
- W2012572826 modified "2023-09-27" @default.
- W2012572826 title "Reactive sulphur species in oxidative signal transduction" @default.
- W2012572826 cites W1524926009 @default.
- W2012572826 cites W1978658307 @default.
- W2012572826 cites W1984135972 @default.
- W2012572826 cites W1990297718 @default.
- W2012572826 cites W1995457093 @default.
- W2012572826 cites W1997822338 @default.
- W2012572826 cites W2009953261 @default.
- W2012572826 cites W2016947117 @default.
- W2012572826 cites W2033712553 @default.
- W2012572826 cites W2033964618 @default.
- W2012572826 cites W2039979152 @default.
- W2012572826 cites W2062807444 @default.
- W2012572826 cites W2106171481 @default.
- W2012572826 doi "https://doi.org/10.1042/bst0321015" @default.
- W2012572826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15506951" @default.
- W2012572826 hasPublicationYear "2004" @default.
- W2012572826 type Work @default.
- W2012572826 sameAs 2012572826 @default.
- W2012572826 citedByCount "29" @default.
- W2012572826 countsByYear W20125728262012 @default.
- W2012572826 countsByYear W20125728262013 @default.
- W2012572826 countsByYear W20125728262015 @default.
- W2012572826 countsByYear W20125728262016 @default.
- W2012572826 countsByYear W20125728262019 @default.
- W2012572826 countsByYear W20125728262020 @default.
- W2012572826 crossrefType "journal-article" @default.
- W2012572826 hasAuthorship W2012572826A5038425390 @default.
- W2012572826 hasAuthorship W2012572826A5044707123 @default.
- W2012572826 hasAuthorship W2012572826A5079348097 @default.
- W2012572826 hasConcept C104317684 @default.
- W2012572826 hasConcept C178790620 @default.
- W2012572826 hasConcept C181199279 @default.
- W2012572826 hasConcept C185592680 @default.
- W2012572826 hasConcept C20719415 @default.
- W2012572826 hasConcept C2776151105 @default.
- W2012572826 hasConcept C2779201268 @default.
- W2012572826 hasConcept C48349386 @default.
- W2012572826 hasConcept C538909803 @default.
- W2012572826 hasConcept C55493867 @default.
- W2012572826 hasConcept C55904794 @default.
- W2012572826 hasConcept C57600042 @default.
- W2012572826 hasConcept C62478195 @default.
- W2012572826 hasConcept C86803240 @default.
- W2012572826 hasConcept C95444343 @default.
- W2012572826 hasConceptScore W2012572826C104317684 @default.
- W2012572826 hasConceptScore W2012572826C178790620 @default.
- W2012572826 hasConceptScore W2012572826C181199279 @default.
- W2012572826 hasConceptScore W2012572826C185592680 @default.
- W2012572826 hasConceptScore W2012572826C20719415 @default.
- W2012572826 hasConceptScore W2012572826C2776151105 @default.
- W2012572826 hasConceptScore W2012572826C2779201268 @default.
- W2012572826 hasConceptScore W2012572826C48349386 @default.
- W2012572826 hasConceptScore W2012572826C538909803 @default.
- W2012572826 hasConceptScore W2012572826C55493867 @default.
- W2012572826 hasConceptScore W2012572826C55904794 @default.
- W2012572826 hasConceptScore W2012572826C57600042 @default.
- W2012572826 hasConceptScore W2012572826C62478195 @default.
- W2012572826 hasConceptScore W2012572826C86803240 @default.
- W2012572826 hasConceptScore W2012572826C95444343 @default.
- W2012572826 hasIssue "6" @default.
- W2012572826 hasLocation W20125728261 @default.
- W2012572826 hasLocation W20125728262 @default.
- W2012572826 hasOpenAccess W2012572826 @default.
- W2012572826 hasPrimaryLocation W20125728261 @default.
- W2012572826 hasRelatedWork W1508875207 @default.
- W2012572826 hasRelatedWork W1581167643 @default.
- W2012572826 hasRelatedWork W1845305891 @default.
- W2012572826 hasRelatedWork W1971892168 @default.
- W2012572826 hasRelatedWork W1983972257 @default.
- W2012572826 hasRelatedWork W1993194916 @default.
- W2012572826 hasRelatedWork W2008567952 @default.
- W2012572826 hasRelatedWork W2113724451 @default.
- W2012572826 hasRelatedWork W2765590223 @default.
- W2012572826 hasRelatedWork W3080308451 @default.
- W2012572826 hasVolume "32" @default.
- W2012572826 isParatext "false" @default.
- W2012572826 isRetracted "false" @default.
- W2012572826 magId "2012572826" @default.
- W2012572826 workType "article" @default.