Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012587625> ?p ?o ?g. }
- W2012587625 endingPage "167" @default.
- W2012587625 startingPage "160" @default.
- W2012587625 abstract "Opioids, dopamine and their receptors are present in many regions of the bulbar respiratory network. The physiological importance of endogenous opioids to respiratory control has not been explicitly demonstrated. Nonetheless, studies of opioidergic respiratory mechanisms are important because synthetic opiate drugs have respiratory side effects that in some situations pose health risks and limit their therapeutic usefulness. They can depress breathing depth and rate, blunt respiratory responsiveness to CO2 and hypoxia, increase upper airway resistance and reduce pulmonary compliance. The opiate respiratory disturbances are mainly due to agonist activation of μ- and δ-subtypes of receptor and involve specific types of respiratory-related neurons in the ventrolateral medulla and the dorsolateral pons. Endogenous dopaminergic modulation in the CNS and carotid bodies enhances CO2-dependent respiratory drive and depresses hypoxic drive. In the CNS, synthetic agonists with selectivity for D1-and D4-types of receptor slow respiratory rhythm, whereas D2-selective agonists modulate acute and chronic responses to hypoxia. D1-receptor agonists also act centrally to increase respiratory responsiveness to CO2, and counteract opiate blunting of CO2-dependent respiratory drive and depression of breathing. Cellular targets and intracellular mechanisms responsible for opioidergic and dopaminergic respiratory effects for the most part remain to be determined." @default.
- W2012587625 created "2016-06-24" @default.
- W2012587625 creator A5002943058 @default.
- W2012587625 date "2008-12-01" @default.
- W2012587625 modified "2023-10-15" @default.
- W2012587625 title "Opioidergic and dopaminergic modulation of respiration" @default.
- W2012587625 cites W1508373794 @default.
- W2012587625 cites W1515729057 @default.
- W2012587625 cites W1564392853 @default.
- W2012587625 cites W1568556641 @default.
- W2012587625 cites W1665093015 @default.
- W2012587625 cites W1791522543 @default.
- W2012587625 cites W1963746743 @default.
- W2012587625 cites W1971130088 @default.
- W2012587625 cites W1973507227 @default.
- W2012587625 cites W1973719004 @default.
- W2012587625 cites W1974183807 @default.
- W2012587625 cites W1974669292 @default.
- W2012587625 cites W1975407474 @default.
- W2012587625 cites W1978691310 @default.
- W2012587625 cites W1980410333 @default.
- W2012587625 cites W1980462575 @default.
- W2012587625 cites W1982937997 @default.
- W2012587625 cites W1983198357 @default.
- W2012587625 cites W1987650831 @default.
- W2012587625 cites W1990772069 @default.
- W2012587625 cites W1992835208 @default.
- W2012587625 cites W1999794614 @default.
- W2012587625 cites W2000744528 @default.
- W2012587625 cites W2004871424 @default.
- W2012587625 cites W2005342985 @default.
- W2012587625 cites W2006410388 @default.
- W2012587625 cites W2007977147 @default.
- W2012587625 cites W2015622305 @default.
- W2012587625 cites W2017391941 @default.
- W2012587625 cites W2020537919 @default.
- W2012587625 cites W2021396618 @default.
- W2012587625 cites W2023522390 @default.
- W2012587625 cites W2027243414 @default.
- W2012587625 cites W2029348258 @default.
- W2012587625 cites W2029475863 @default.
- W2012587625 cites W2032463524 @default.
- W2012587625 cites W2033390513 @default.
- W2012587625 cites W2037124660 @default.
- W2012587625 cites W2037688283 @default.
- W2012587625 cites W2039231750 @default.
- W2012587625 cites W2040734324 @default.
- W2012587625 cites W2043004090 @default.
- W2012587625 cites W2045089422 @default.
- W2012587625 cites W2045742399 @default.
- W2012587625 cites W2046607811 @default.
- W2012587625 cites W2048801729 @default.
- W2012587625 cites W2050651031 @default.
- W2012587625 cites W2051951527 @default.
- W2012587625 cites W2053073047 @default.
- W2012587625 cites W2053828933 @default.
- W2012587625 cites W2055378312 @default.
- W2012587625 cites W2057044780 @default.
- W2012587625 cites W2060094414 @default.
- W2012587625 cites W2061699966 @default.
- W2012587625 cites W2064409105 @default.
- W2012587625 cites W2067555483 @default.
- W2012587625 cites W2073242056 @default.
- W2012587625 cites W2075454737 @default.
- W2012587625 cites W2075759948 @default.
- W2012587625 cites W2075940571 @default.
- W2012587625 cites W2076494387 @default.
- W2012587625 cites W2079684345 @default.
- W2012587625 cites W2080003039 @default.
- W2012587625 cites W2094037774 @default.
- W2012587625 cites W2094629840 @default.
- W2012587625 cites W2108957007 @default.
- W2012587625 cites W2111095535 @default.
- W2012587625 cites W2113408846 @default.
- W2012587625 cites W2116357523 @default.
- W2012587625 cites W2119887234 @default.
- W2012587625 cites W2126376455 @default.
- W2012587625 cites W2132984603 @default.
- W2012587625 cites W2134610747 @default.
- W2012587625 cites W2135873872 @default.
- W2012587625 cites W2143140948 @default.
- W2012587625 cites W2143290315 @default.
- W2012587625 cites W2146517666 @default.
- W2012587625 cites W2146631034 @default.
- W2012587625 cites W2150799234 @default.
- W2012587625 cites W2151398015 @default.
- W2012587625 cites W2159669477 @default.
- W2012587625 cites W2162769563 @default.
- W2012587625 cites W2165398609 @default.
- W2012587625 cites W2165542532 @default.
- W2012587625 cites W2170698109 @default.
- W2012587625 cites W2179988366 @default.
- W2012587625 cites W2197303628 @default.
- W2012587625 cites W2206017601 @default.
- W2012587625 cites W2229069580 @default.
- W2012587625 cites W2291278322 @default.
- W2012587625 cites W2404527422 @default.
- W2012587625 cites W4236702479 @default.