Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012590163> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2012590163 endingPage "39" @default.
- W2012590163 startingPage "33" @default.
- W2012590163 abstract "Peripheral blood lymphocytes of cancer patients were sensitized in vitro to autologous tumour cells in mixed lymphocyte-tumour culture (MLTC). Blast cells were isolated on discontinuous Percoll gradients from MLTC which showed significant stimulation of [3H]-thymidine incorporation. Cultured T cells (CTC) were derived from these blasts by growth in conditioned medium containing interleukin-2 (IL-2) and maintained for up to 51 days by repeated feeding with IL-2 and in some cases by addition of irradiated allogeneic blood mononuclear cells as fillers. These cultures showed specific cytotoxic reactivity against autologous tumour and in only a few cases was natural killing (NK) of K562 cells apparent. Restimulation of CTC with tumour was measured in primed lymphocyte test (PLT). Increased uptake of [3H]-thymidine was found upon stimulation by autologous tumour and allogeneic tumour of the same site and histology but there was no response to non-related tumours or to a panel of allogeneic lymphocytes. No sensitization to autologous HLA-D/DR could be detected by restimulation or cytotoxicity against monocytes in the majority of cases. These data suggest that, by careful selection of sensitised blasts from MLTC, it is possible to obtain CTC with both helper (proliferative) and cytotoxic T cells and that such CTC have specific reactivity against tumour cells. These cellular reagents will be useful in defining the antigenicity of human neoplasms and possibly in therapy." @default.
- W2012590163 created "2016-06-24" @default.
- W2012590163 creator A5002903364 @default.
- W2012590163 creator A5013534923 @default.
- W2012590163 date "1982-01-15" @default.
- W2012590163 modified "2023-09-30" @default.
- W2012590163 title "Specific cytotoxicity against autologous tumour and proliferative responses of human lymphocytes grown in interleukin 2" @default.
- W2012590163 cites W1966055255 @default.
- W2012590163 cites W1977472316 @default.
- W2012590163 cites W1980535421 @default.
- W2012590163 cites W1996753623 @default.
- W2012590163 cites W2018751787 @default.
- W2012590163 cites W2025952939 @default.
- W2012590163 cites W2037195433 @default.
- W2012590163 cites W2039347776 @default.
- W2012590163 cites W2039375827 @default.
- W2012590163 cites W2042264911 @default.
- W2012590163 cites W2052573541 @default.
- W2012590163 cites W2069431617 @default.
- W2012590163 cites W2082541413 @default.
- W2012590163 cites W2092439260 @default.
- W2012590163 cites W2157760271 @default.
- W2012590163 cites W2162784874 @default.
- W2012590163 cites W2303550136 @default.
- W2012590163 doi "https://doi.org/10.1002/ijc.2910290107" @default.
- W2012590163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6460704" @default.
- W2012590163 hasPublicationYear "1982" @default.
- W2012590163 type Work @default.
- W2012590163 sameAs 2012590163 @default.
- W2012590163 citedByCount "81" @default.
- W2012590163 countsByYear W20125901632012 @default.
- W2012590163 countsByYear W20125901632014 @default.
- W2012590163 countsByYear W20125901632016 @default.
- W2012590163 countsByYear W20125901632017 @default.
- W2012590163 crossrefType "journal-article" @default.
- W2012590163 hasAuthorship W2012590163A5002903364 @default.
- W2012590163 hasAuthorship W2012590163A5013534923 @default.
- W2012590163 hasConcept C109316439 @default.
- W2012590163 hasConcept C137061746 @default.
- W2012590163 hasConcept C154317977 @default.
- W2012590163 hasConcept C202751555 @default.
- W2012590163 hasConcept C203014093 @default.
- W2012590163 hasConcept C2777371288 @default.
- W2012590163 hasConcept C2777761686 @default.
- W2012590163 hasConcept C49382859 @default.
- W2012590163 hasConcept C55493867 @default.
- W2012590163 hasConcept C86803240 @default.
- W2012590163 hasConcept C8891405 @default.
- W2012590163 hasConceptScore W2012590163C109316439 @default.
- W2012590163 hasConceptScore W2012590163C137061746 @default.
- W2012590163 hasConceptScore W2012590163C154317977 @default.
- W2012590163 hasConceptScore W2012590163C202751555 @default.
- W2012590163 hasConceptScore W2012590163C203014093 @default.
- W2012590163 hasConceptScore W2012590163C2777371288 @default.
- W2012590163 hasConceptScore W2012590163C2777761686 @default.
- W2012590163 hasConceptScore W2012590163C49382859 @default.
- W2012590163 hasConceptScore W2012590163C55493867 @default.
- W2012590163 hasConceptScore W2012590163C86803240 @default.
- W2012590163 hasConceptScore W2012590163C8891405 @default.
- W2012590163 hasIssue "1" @default.
- W2012590163 hasLocation W20125901631 @default.
- W2012590163 hasLocation W20125901632 @default.
- W2012590163 hasOpenAccess W2012590163 @default.
- W2012590163 hasPrimaryLocation W20125901631 @default.
- W2012590163 hasRelatedWork W1990434843 @default.
- W2012590163 hasRelatedWork W1990565583 @default.
- W2012590163 hasRelatedWork W1994802948 @default.
- W2012590163 hasRelatedWork W2039747916 @default.
- W2012590163 hasRelatedWork W2053031032 @default.
- W2012590163 hasRelatedWork W2126966733 @default.
- W2012590163 hasRelatedWork W2410833002 @default.
- W2012590163 hasRelatedWork W2415361595 @default.
- W2012590163 hasRelatedWork W4251449568 @default.
- W2012590163 hasRelatedWork W2185779647 @default.
- W2012590163 hasVolume "29" @default.
- W2012590163 isParatext "false" @default.
- W2012590163 isRetracted "false" @default.
- W2012590163 magId "2012590163" @default.
- W2012590163 workType "article" @default.