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• W2012591268 abstract "Genotoxicity of ibuprofen was evaluated by employing the mouse in vivo chromosomal aberration (CA) test. Ibuprofen administered orally at doses of 10, 20, 40, and 60 mg/kg body weight to mice resulted in mitotic depression and induction of CAs. A dose-related decrease in mitotic index (MI) and an increase in the frequencies of chromosomal aberrations per cell (CAs/cell) were recorded in bone marrow cells. However, a statistically significant reduction in MI and an increase in CAs/cell were found for both the higher doses. The results obtained indicate that ibuprofen is capable of inducing dose-dependent genotoxicity in bone marrow cells of mice." @default.
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• W2012591268 date "2012-01-27" @default.
• W2012591268 modified "2023-09-26" @default.
• W2012591268 title "Genotoxicity of ibuprofen in mouse bone marrow cells<i>in vivo</i>" @default.
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• W2012591268 doi "https://doi.org/10.3109/01480545.2011.630670" @default.
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