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• W2012591372 abstract "Cardiac hypertrophy was induced in rats by daily injections of L-triiodothyronine (0.2 mg/kg body wt, s.c., 1 to 3 days). Regression of hypertrophy was studied after 3 days of injection for a period of 1 to 16 days. Cardiac RNA was isolated by phenolextraction, mRNA by affinity chromatography of cardiac total RNA on oligo-dT-cellulose. In addition, cardiac mRNA was also quantitated by hybridization to 3H-Poly(U). After 3 days of T3-treatment, the extractable amount of cardiac total RNA increased from 759 ± 181 μg/g heart (controls) to 980 ± 119 μg/g heart (T3-rats), and that of mRNA from 24.7 ± 2.0 (controls) to 39.4 ± 7.0 (T3-rats), increases of 29.1% (total RNA) and 59.5% (mRNA). 16 days after cessation of T3-treatment, total RNA and mRNA levels had returned to normal. The increase in cardiac mRNA in T3-rats was investigated in further detail by in vitro translation of the isolated mRNA in the mRNA-dependent reticulocyte lysate system. Incorporation of 35S-methionine into total protein was identical for cardiac mRNA from control and T3-rats. Separation of the in vitro synthesized proteins on SDS-Polyacrylamide-Slabgels revealed the complete synthesis of actin, troponin-T, tropomyosin, myoglobin and myosin-light-chains 1 and 2. The mRNAs coding for these proteins represented identical fractions of total mRNA in control and T3-rats. This leads to the conclusion that T3 had stimulated the synthesis of all of these specific mRNAs in an unselective manner. From our data and from the results of other authors we conclude that changes in cardiac mRNA levels are the major regulatory factor in causing changes in cardiac protein synthesis rates leading to cardiac hypertrophy in hyperthyroidism." @default.
• W2012591372 created "2016-06-24" @default.
• W2012591372 creator A5016782638 @default.
• W2012591372 creator A5073736610 @default.
• W2012591372 date "1982-10-01" @default.
• W2012591372 modified "2023-10-14" @default.
• W2012591372 title "The effect of triiodothyronine on the cardiac mRNA" @default.
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• W2012591372 doi "https://doi.org/10.1016/0022-2828(82)90143-2" @default.
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