Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012597831> ?p ?o ?g. }
- W2012597831 endingPage "e122" @default.
- W2012597831 startingPage "e122" @default.
- W2012597831 abstract "Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of serotonin transmission in the CNS is reported to be related to different psychiatric disorders in humans including depression, impulsive aggression and anxiety disorders. The most frequently prescribed antidepressants and anxiolytics target the serotonergic system. However, these drugs are not effective in 20–30% of cases. The causes of this failure as well as the molecular mechanisms involved in the origin of psychological disorders are poorly understood. Biosynthesis of serotonin in the CNS is initiated by tryptophan hydroxylase 2 (TPH2). In this study, we used Tph2-deficient (Tph2−/−) mice to evaluate the impact of serotonin depletion in the brain on mouse behavior. Tph2−/− mice exhibited increased depression-like behavior in the forced swim test but not in the tail suspension test. In addition, they showed decreased anxiety-like behavior in three different paradigms: elevated plus maze, marble burying and novelty-suppressed feeding tests. These phenotypes were accompanied by strong aggressiveness observed in the resident–intruder paradigm. Despite carrying only one copy of the gene, heterozygous Tph2+/− mice showed only 10% reduction in brain serotonin, which was not sufficient to modulate behavior in the tested paradigms. Our findings provide unequivocal evidence on the pivotal role of central serotonin in anxiety and aggression." @default.
- W2012597831 created "2016-06-24" @default.
- W2012597831 creator A5012362079 @default.
- W2012597831 creator A5039371456 @default.
- W2012597831 creator A5048876339 @default.
- W2012597831 creator A5059936166 @default.
- W2012597831 creator A5070435740 @default.
- W2012597831 creator A5086591496 @default.
- W2012597831 creator A5088220989 @default.
- W2012597831 date "2012-05-29" @default.
- W2012597831 modified "2023-09-26" @default.
- W2012597831 title "Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin" @default.
- W2012597831 cites W1677098962 @default.
- W2012597831 cites W1879874234 @default.
- W2012597831 cites W1969750389 @default.
- W2012597831 cites W1970645678 @default.
- W2012597831 cites W1972903927 @default.
- W2012597831 cites W1974809581 @default.
- W2012597831 cites W1976114760 @default.
- W2012597831 cites W1976584236 @default.
- W2012597831 cites W1976955283 @default.
- W2012597831 cites W1978219303 @default.
- W2012597831 cites W1985622833 @default.
- W2012597831 cites W1990944933 @default.
- W2012597831 cites W1991155688 @default.
- W2012597831 cites W1992617664 @default.
- W2012597831 cites W1995120027 @default.
- W2012597831 cites W1995909110 @default.
- W2012597831 cites W1998712336 @default.
- W2012597831 cites W2004886688 @default.
- W2012597831 cites W2005442679 @default.
- W2012597831 cites W2005827175 @default.
- W2012597831 cites W2008803292 @default.
- W2012597831 cites W2011812102 @default.
- W2012597831 cites W2014495783 @default.
- W2012597831 cites W2017426275 @default.
- W2012597831 cites W2018571819 @default.
- W2012597831 cites W2019551126 @default.
- W2012597831 cites W2019671395 @default.
- W2012597831 cites W2020944445 @default.
- W2012597831 cites W2027791182 @default.
- W2012597831 cites W2028054765 @default.
- W2012597831 cites W2032842997 @default.
- W2012597831 cites W2035581455 @default.
- W2012597831 cites W2035663126 @default.
- W2012597831 cites W2035738053 @default.
- W2012597831 cites W2036245134 @default.
- W2012597831 cites W2036691617 @default.
- W2012597831 cites W2036744872 @default.
- W2012597831 cites W2039607878 @default.
- W2012597831 cites W2041561931 @default.
- W2012597831 cites W2043807226 @default.
- W2012597831 cites W2046846885 @default.
- W2012597831 cites W2046955370 @default.
- W2012597831 cites W2051541361 @default.
- W2012597831 cites W2053714798 @default.
- W2012597831 cites W2053744108 @default.
- W2012597831 cites W2054923626 @default.
- W2012597831 cites W2057008284 @default.
- W2012597831 cites W2068535052 @default.
- W2012597831 cites W2074245141 @default.
- W2012597831 cites W2074831193 @default.
- W2012597831 cites W2074985670 @default.
- W2012597831 cites W2076246669 @default.
- W2012597831 cites W2077425100 @default.
- W2012597831 cites W2082250521 @default.
- W2012597831 cites W2082841063 @default.
- W2012597831 cites W2094992497 @default.
- W2012597831 cites W2095340530 @default.
- W2012597831 cites W2097135736 @default.
- W2012597831 cites W2107277218 @default.
- W2012597831 cites W2111478092 @default.
- W2012597831 cites W2111875952 @default.
- W2012597831 cites W2114462724 @default.
- W2012597831 cites W2114589447 @default.
- W2012597831 cites W2114773717 @default.
- W2012597831 cites W2117296179 @default.
- W2012597831 cites W2121608010 @default.
- W2012597831 cites W2122383036 @default.
- W2012597831 cites W2126816262 @default.
- W2012597831 cites W2139834393 @default.
- W2012597831 cites W2140338624 @default.
- W2012597831 cites W2144312659 @default.
- W2012597831 cites W2150997715 @default.
- W2012597831 cites W2151259804 @default.
- W2012597831 cites W2155181385 @default.
- W2012597831 cites W2158647822 @default.
- W2012597831 cites W2168358363 @default.
- W2012597831 cites W2171055927 @default.
- W2012597831 cites W2793634050 @default.
- W2012597831 cites W4244965311 @default.
- W2012597831 doi "https://doi.org/10.1038/tp.2012.44" @default.
- W2012597831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3365263" @default.
- W2012597831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22832966" @default.
- W2012597831 hasPublicationYear "2012" @default.
- W2012597831 type Work @default.
- W2012597831 sameAs 2012597831 @default.
- W2012597831 citedByCount "199" @default.