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- W2012602779 abstract "In order to reduce the ulcerogenic effect of ibuprofen, its carboxylic group has been converted into 5-membered and 6-membered heterocyclic rings. Various 1,3,4-thiadaizo (y), imidazo [2,1-b] [1,3,4] thiadiazoles (1a-d), 1,3-oxazin-2-yl (2), quinazolin-2-yl (3, 4 and 5), hydrazine, pyrazole (6), pyrazone (7, 8) and oxadiazole (9, 12). Derivatives of ibuprofen were prepared by cyclization under various reaction conditions in a very good yield. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity. Compounds (4, 5, and 8) showed the highest antibacterial activities compared to other compounds and standard drugs. However, compound (1b) showed the lowest antibacterial activity compared to other compounds. All compounds have been characterized by IR, 1H NMR and C.H.N analysis." @default.
- W2012602779 created "2016-06-24" @default.
- W2012602779 creator A5065807259 @default.
- W2012602779 date "2014-01-01" @default.
- W2012602779 modified "2023-10-01" @default.
- W2012602779 title "Synthesis and antimicrobial activity of Ibuprofen derivatives" @default.
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- W2012602779 doi "https://doi.org/10.4236/ns.2014.62008" @default.
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