FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012602951> ?p ?o ?g. }

• W2012602951 endingPage "2697" @default.
• W2012602951 startingPage "2688" @default.
• W2012602951 abstract "Sleep has a pivotal role in the consolidation of declarative memory. The coordinated neuronal replay of information encoded before sleep has been identified as a key process. It is assumed that the repeated reactivation of firing patterns in glutamatergic neuron assemblies translates into plastic synaptic changes underlying the formation of longer-term neuronal representations. Here, we tested the effects of blocking and enhancing glutamatergic neurotransmission during sleep on declarative memory consolidation in humans. We conducted three placebo-controlled, crossover, double-blind studies in which participants learned a word-pair association task. Afterwards, they slept in a sleep laboratory and received glutamatergic modulators. Our first two studies aimed at impairing consolidation by administering the NMDA receptor blocker ketamine and the AMPA receptor blocker caroverine during retention sleep, which, paradoxically, remained unsuccessful, inasmuch as declarative memory performance was unaffected by the treatment. However, in the third study, administration of the NMDA receptor coagonist D-cycloserine (DCS) during retention sleep facilitated consolidation of declarative memory (word pairs) but not consolidation of a procedural control task (finger sequence tapping). Administration of DCS during a wake interval remained without effect on retention of word pairs but improved encoding of numbers. From the overall pattern, we conclude that the consolidation of hippocampus-dependent declarative memory during sleep relies on NMDA-related plastic processes that differ from those processes leading to wake encoding. We speculate that glutamatergic activation during sleep is not only involved in consolidation but also in forgetting of hippocampal memory with both processes being differentially sensitive to DCS and unselective blockade of NMDA and AMPA receptors." @default.
• W2012602951 created "2016-06-24" @default.
• W2012602951 creator A5012687917 @default.
• W2012602951 creator A5036040037 @default.
• W2012602951 creator A5039177178 @default.
• W2012602951 creator A5047309612 @default.
• W2012602951 date "2013-07-26" @default.
• W2012602951 modified "2023-10-17" @default.
• W2012602951 title "Sleep-Dependent Declarative Memory Consolidation—Unaffected after Blocking NMDA or AMPA Receptors but Enhanced by NMDA Coagonist D-Cycloserine" @default.
• W2012602951 cites W1533892631 @default.
• W2012602951 cites W1928206330 @default.
• W2012602951 cites W1964122385 @default.
• W2012602951 cites W1974491267 @default.
• W2012602951 cites W1975136983 @default.
• W2012602951 cites W1980586443 @default.
• W2012602951 cites W1986541829 @default.
• W2012602951 cites W1990294595 @default.
• W2012602951 cites W1996116470 @default.
• W2012602951 cites W2000775105 @default.
• W2012602951 cites W2002716918 @default.
• W2012602951 cites W2005609503 @default.
• W2012602951 cites W2007301240 @default.
• W2012602951 cites W2009102686 @default.
• W2012602951 cites W2012748324 @default.
• W2012602951 cites W2016554932 @default.
• W2012602951 cites W2017766656 @default.
• W2012602951 cites W2018162107 @default.
• W2012602951 cites W2026677898 @default.
• W2012602951 cites W2027685064 @default.
• W2012602951 cites W2028594041 @default.
• W2012602951 cites W2033615215 @default.
• W2012602951 cites W2035272956 @default.
• W2012602951 cites W2035681769 @default.
• W2012602951 cites W2037557484 @default.
• W2012602951 cites W2039956044 @default.
• W2012602951 cites W2043738025 @default.
• W2012602951 cites W2049753507 @default.
• W2012602951 cites W2050066016 @default.
• W2012602951 cites W2053308210 @default.
• W2012602951 cites W2056769976 @default.
• W2012602951 cites W2061882718 @default.
• W2012602951 cites W2066376418 @default.
• W2012602951 cites W2071290167 @default.
• W2012602951 cites W2076327464 @default.
• W2012602951 cites W2078889033 @default.
• W2012602951 cites W2080031358 @default.
• W2012602951 cites W2086009184 @default.
• W2012602951 cites W2087484885 @default.
• W2012602951 cites W2088046534 @default.
• W2012602951 cites W2096698697 @default.
• W2012602951 cites W2097201141 @default.
• W2012602951 cites W2097399653 @default.
• W2012602951 cites W2103566565 @default.
• W2012602951 cites W2106011868 @default.
• W2012602951 cites W2109982075 @default.
• W2012602951 cites W2110724392 @default.
• W2012602951 cites W2112730272 @default.
• W2012602951 cites W2123296304 @default.
• W2012602951 cites W2125389278 @default.
• W2012602951 cites W2130378946 @default.
• W2012602951 cites W2137939559 @default.
• W2012602951 cites W2141824480 @default.
• W2012602951 cites W2149921408 @default.
• W2012602951 cites W2151178348 @default.
• W2012602951 cites W2152778425 @default.
• W2012602951 cites W2152804275 @default.
• W2012602951 cites W2154323234 @default.
• W2012602951 cites W2155113153 @default.
• W2012602951 cites W2158253208 @default.
• W2012602951 cites W2161113761 @default.
• W2012602951 cites W2161849272 @default.
• W2012602951 cites W2168101731 @default.
• W2012602951 cites W2168301247 @default.
• W2012602951 cites W2171697010 @default.
• W2012602951 cites W4292994367 @default.
• W2012602951 cites W4297154240 @default.
• W2012602951 doi "https://doi.org/10.1038/npp.2013.179" @default.
• W2012602951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3828540" @default.
• W2012602951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23887151" @default.
• W2012602951 hasPublicationYear "2013" @default.
• W2012602951 type Work @default.
• W2012602951 sameAs 2012602951 @default.
• W2012602951 citedByCount "38" @default.
• W2012602951 countsByYear W20126029512014 @default.
• W2012602951 countsByYear W20126029512015 @default.
• W2012602951 countsByYear W20126029512016 @default.
• W2012602951 countsByYear W20126029512017 @default.
• W2012602951 countsByYear W20126029512018 @default.
• W2012602951 countsByYear W20126029512019 @default.
• W2012602951 countsByYear W20126029512020 @default.
• W2012602951 countsByYear W20126029512021 @default.
• W2012602951 countsByYear W20126029512022 @default.
• W2012602951 countsByYear W20126029512023 @default.
• W2012602951 crossrefType "journal-article" @default.
• W2012602951 hasAuthorship W2012602951A5012687917 @default.
• W2012602951 hasAuthorship W2012602951A5036040037 @default.
• W2012602951 hasAuthorship W2012602951A5039177178 @default.
• W2012602951 hasAuthorship W2012602951A5047309612 @default.

• next