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• W2012604683 abstract "A new strategy to combine Zn2+ assistant DNA recycling followed with hybridization chain reaction dual amplification was designed for highly sensitive electrochemical detection of target DNA. A gold electrode was used to immobilize molecular beacon (MB) as the recognition probe and perform the amplification procedure. In the presence of the target DNA, the hairpin probe 1 was opened, and the DNAzyme was liberated from the caged structure. The activated DNAzyme hybridized with the MB and catalyzed its cleavage in the presence of Zn2+ cofactor and resulting in a free DNAzyme strand. Finally, each target-induced activated DNAzyme underwent many cycles triggering the cleavage of MB, thus forming numerous MB fragments. The MB fragments triggered the HCR and formed a long double-helix DNA structure. Because both H1 and H2 were labeled by biotin, a lot of SA-ALP was captured on the electrode surface, thus catalyzing a silver deposition process for electrochemical stripping analysis. This novel cascade signal amplification strategy can detect target DNA down to the attomolar level with a dynamic range spanning 6 orders of magnitude. This highly sensitive and specific assay has a great potential to become a promising DNA quantification method in biomedical research and clinical diagnosis." @default.
• W2012604683 created "2016-06-24" @default.
• W2012604683 creator A5017523144 @default.
• W2012604683 creator A5053849334 @default.
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• W2012604683 date "2015-01-01" @default.
• W2012604683 modified "2023-10-01" @default.
• W2012604683 title "Ultrasensitive electrochemical detection of DNA based on Zn 2+ assistant DNA recycling followed with hybridization chain reaction dual amplification" @default.
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• W2012604683 doi "https://doi.org/10.1016/j.bios.2014.07.078" @default.
• W2012604683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25128622" @default.
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