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- W2012605726 abstract "We visualized intracellular Ca 2+ concentration ([Ca 2+ ] i ) changes, using fluo‐3 as an indicator, of individual vascular smooth muscle cells and endothelial cells within intact rat tail arteries by confocal microscopy. Using a piezo‐driven objective, we focused on endothelial and smooth muscle cell layers alternately to obtain Ca 2+ images of their cells. In the presence of 1 μ m acetylcholine (ACh), individual endothelial cells responded with intermittent increases in the [Ca 2+ ] i (Ca 2+ oscillations). At the same time, the frequency of Ca 2+ oscillations in smooth muscle cells induced by electrical stimulation of the perivascular sympathetic nerve was greatly decreased. A [Ca 2+ ] i rise during the oscillations in the endothelial cells propagated in the form of a wave along the long axis of the cells. In the presence of a NO synthase inhibitor, no significant inhibitory effect of ACh on the Ca 2+ signalling in the vascular smooth muscle cells was detected, although the Ca 2+ oscillations in the endothelial cells persisted. The inhibitory effect of ACh on the frequency of Ca 2+ oscillations in the vascular smooth muscle cells was mimicked by 1 μ m sodium nitroprusside, a NO donor. These results indicate that Ca 2+ waves and oscillations in vascular endothelial cells regulate NO production, which modulates vascular tone by decreasing the frequency of Ca 2+ oscillations in smooth muscle cells activated by sympathetic agonists." @default.
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- W2012605726 date "1997-10-01" @default.
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- W2012605726 title "Endothelium-dependent frequency modulation of Ca<sup>2+</sup>signalling in individual vascular smooth muscle cells of the rat" @default.
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- W2012605726 doi "https://doi.org/10.1111/j.1469-7793.1997.349be.x" @default.
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