FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012605854> ?p ?o ?g. }

• W2012605854 endingPage "73" @default.
• W2012605854 startingPage "67" @default.
• W2012605854 abstract "In Brief Aims To evaluate the vascular effects of doxazosin, an alpha-1 antagonist, in hypertensive patients with metabolic syndrome in whom the drug has previously been shown to exert beneficial metabolic actions on lipids and insulin metabolism. Experimental protocol Twelve untreated non-diabetic hypertensive patients with National Cholesterol Education Program (NCEP) ATP-III defined metabolic syndrome were assigned to three-months of treatment with doxazosin (5.5±1.9 mg/die). Study variables were measured at baseline and after treatment. End-points: forearm blood flow (strain-gauge plethysmography) responses to graded intra-arterial acetylcholine and sodium nitroprusside infusion to test endothelium-dependent and independent vasodilatation respectively. Minimum forearm vascular resistance, the ratio of mean blood pressure and post-ischaemic maximal blood flow, as an index of arteriolar structure; transcapillary albumin escape rate (the 1-h decay rate of 125I-albumin, 6–8 μC ev) as a measure of systemic capillary permeability. Lipids, fasting and post-glucose insulin were measured at baseline and after treatment. Results Doxazosin reduced blood pressure, augmented acetylcholine-mediated vasodilatation, decreased minimum resistance and, although not to a statistically significant extent, transvascular albumin leakage increased high-density lipoprotein (HDL) cholesterol while triglycerides and post-stimulative hyperinsulinemia decreased. Conclusions Doxazosin improved endothelial-mediated vasomotor function and reversed abnormal arteriolar structure in hypertensive patients with metabolic syndrome while improving lipid profile and blunting post-glucose hyperinsulinemia. Three month-treatment with doxazosin, an alpha-1 antagonist, reduced blood pressure, augmented endothelial-mediated forearm responses, decreased minimum fores resistance, an index of arteriolar remodelling, tended to normalize and abnormal systemic capillary permeability while improving the metabolic profile in non diabetic hypertensive patients with ATP-III defined Metabolic Syndrome." @default.
• W2012605854 created "2016-06-24" @default.
• W2012605854 creator A5004209189 @default.
• W2012605854 creator A5034383160 @default.
• W2012605854 creator A5043831233 @default.
• W2012605854 creator A5045562945 @default.
• W2012605854 creator A5056234854 @default.
• W2012605854 creator A5070377136 @default.
• W2012605854 creator A5091607246 @default.
• W2012605854 date "2005-02-01" @default.
• W2012605854 modified "2023-10-18" @default.
• W2012605854 title "The vascular effects of doxazosin in hypertension complicated by metabolic syndrome" @default.
• W2012605854 cites W1582020189 @default.
• W2012605854 cites W1765750524 @default.
• W2012605854 cites W1990131827 @default.
• W2012605854 cites W1993658009 @default.
• W2012605854 cites W1997850012 @default.
• W2012605854 cites W2010921303 @default.
• W2012605854 cites W2014643180 @default.
• W2012605854 cites W2022006192 @default.
• W2012605854 cites W2025570653 @default.
• W2012605854 cites W2037820011 @default.
• W2012605854 cites W2041126802 @default.
• W2012605854 cites W2063577291 @default.
• W2012605854 cites W2075796090 @default.
• W2012605854 cites W2100926526 @default.
• W2012605854 cites W2101978769 @default.
• W2012605854 cites W2108964996 @default.
• W2012605854 cites W2142433318 @default.
• W2012605854 cites W2156121263 @default.
• W2012605854 cites W2159883603 @default.
• W2012605854 cites W2164597948 @default.
• W2012605854 cites W2166043341 @default.
• W2012605854 cites W2169182236 @default.
• W2012605854 cites W2315475821 @default.
• W2012605854 cites W4238251256 @default.
• W2012605854 doi "https://doi.org/10.1097/00019501-200502000-00012" @default.
• W2012605854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15654203" @default.
• W2012605854 hasPublicationYear "2005" @default.
• W2012605854 type Work @default.
• W2012605854 sameAs 2012605854 @default.
• W2012605854 citedByCount "21" @default.
• W2012605854 countsByYear W20126058542012 @default.
• W2012605854 countsByYear W20126058542013 @default.
• W2012605854 countsByYear W20126058542014 @default.
• W2012605854 countsByYear W20126058542018 @default.
• W2012605854 countsByYear W20126058542019 @default.
• W2012605854 crossrefType "journal-article" @default.
• W2012605854 hasAuthorship W2012605854A5004209189 @default.
• W2012605854 hasAuthorship W2012605854A5034383160 @default.
• W2012605854 hasAuthorship W2012605854A5043831233 @default.
• W2012605854 hasAuthorship W2012605854A5045562945 @default.
• W2012605854 hasAuthorship W2012605854A5056234854 @default.
• W2012605854 hasAuthorship W2012605854A5070377136 @default.
• W2012605854 hasAuthorship W2012605854A5091607246 @default.
• W2012605854 hasConcept C120770815 @default.
• W2012605854 hasConcept C126322002 @default.
• W2012605854 hasConcept C134018914 @default.
• W2012605854 hasConcept C2777391703 @default.
• W2012605854 hasConcept C2777590997 @default.
• W2012605854 hasConcept C2779306644 @default.
• W2012605854 hasConcept C2780578515 @default.
• W2012605854 hasConcept C2780988686 @default.
• W2012605854 hasConcept C555293320 @default.
• W2012605854 hasConcept C58245268 @default.
• W2012605854 hasConcept C71924100 @default.
• W2012605854 hasConcept C84393581 @default.
• W2012605854 hasConceptScore W2012605854C120770815 @default.
• W2012605854 hasConceptScore W2012605854C126322002 @default.
• W2012605854 hasConceptScore W2012605854C134018914 @default.
• W2012605854 hasConceptScore W2012605854C2777391703 @default.
• W2012605854 hasConceptScore W2012605854C2777590997 @default.
• W2012605854 hasConceptScore W2012605854C2779306644 @default.
• W2012605854 hasConceptScore W2012605854C2780578515 @default.
• W2012605854 hasConceptScore W2012605854C2780988686 @default.
• W2012605854 hasConceptScore W2012605854C555293320 @default.
• W2012605854 hasConceptScore W2012605854C58245268 @default.
• W2012605854 hasConceptScore W2012605854C71924100 @default.
• W2012605854 hasConceptScore W2012605854C84393581 @default.
• W2012605854 hasIssue "1" @default.
• W2012605854 hasLocation W20126058541 @default.
• W2012605854 hasLocation W20126058542 @default.
• W2012605854 hasOpenAccess W2012605854 @default.
• W2012605854 hasPrimaryLocation W20126058541 @default.
• W2012605854 hasRelatedWork W1991367927 @default.
• W2012605854 hasRelatedWork W2012273189 @default.
• W2012605854 hasRelatedWork W2014369012 @default.
• W2012605854 hasRelatedWork W2032225465 @default.
• W2012605854 hasRelatedWork W2056849036 @default.
• W2012605854 hasRelatedWork W2094672900 @default.
• W2012605854 hasRelatedWork W2126254671 @default.
• W2012605854 hasRelatedWork W2151350502 @default.
• W2012605854 hasRelatedWork W2410789767 @default.
• W2012605854 hasRelatedWork W2418646588 @default.
• W2012605854 hasVolume "16" @default.
• W2012605854 isParatext "false" @default.
• W2012605854 isRetracted "false" @default.
• W2012605854 magId "2012605854" @default.

• next